Olivia Justynski, Kate Bridges ... Valerie Horsley
After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.
A regionally resolved single-cell RNA-sequencing analysis of GBM-associated leukocytes reveals distinct activation states of the main immune populations between tumor center, peripheral infiltration zone and blood.
Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.
Benjamin D Wheeler, John D Gagnon ... K Mark Ansel
A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.
Maya L Bulos, Edyta M Grzelak ... Michael J Bollong
Screening repurposed drugs identifies that a clinical stage inhibitor splicing related kinases unexpectedly activates YAP driven transcription in cells.
A biochemical probe targeting Tregs shows the importance of Tregs for B cell homeostasis and peripheral B cell reduction is caused by an activated T-cell-dependent mechanism.
HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.
Daniel Muñoz-Reyes, Levi J McClelland ... Maria Jose Sanchez-Barrena
Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.
Elizaveta V Bashkirova, Nell Klimpert ... Stavros Lomvardas
Dorsoventral gradients of transcription factors NFIA, B, and X impose epigenetic and transcriptional spatial restrictions to olfactory receptor expression.
