Browse our Research Articles

Page 228 of 1,471
    1. Neuroscience

    Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making

    Mariann Oemisch, Hyojung Seo
    The NMDA receptor might preferentially mediate immediate experience/impact of events with negative over positive valence.
    1. Structural Biology and Molecular Biophysics

    The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

    Marco van den Noort, Panagiotis Drougkas ... Bert Poolman
    Transient and weak interactions between the substrate-binding proteins of the ATP-binding cassette transporter OpuA can influence the transport efficiency.
    1. Cell Biology

    Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function

    Rita De Gasperi, Laszlo Csernoch ... Christopher P Cardozo
    Genetic reduction of Numb or Numb/Nubl is linked to deterioration of the Septin cytoskeleton and suggests cytoskeletal abnormalities are the consequences of and contribute to age-related changes in skeletal muscle.
    1. Neuroscience

    Representational drift as a result of implicit regularization

    Aviv Ratzon, Dori Derdikman, Omri Barak
    Continuous noisy learning in neural networks leads to slow, directed qualitative changes in their internal representations, without affecting their quality.
    1. Microbiology and Infectious Disease

    Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

    Michael D Sacco, Lauren R Hammond ... Yu Chen
    The N-terminal domain of Staphylococcus aureus GpsB, a scaffolding protein, forms an atypical asymmetric dimer and binds to the C-termini of FtsZ and PBP4, influencing the localization and regulation of both the Z-ring and cell wall synthesis.
    1. Cell Biology

    BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

    Ruichen Yang, Hongshang Chu ... Baojie Li
    Uncovering a new function of BMP signaling and enhancing our comprehension of the pathogenesis of microtia.
    1. Medicine

    Fungal–bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

    Peigen Chen, Haicheng Chen ... Xing Yang
    Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Experimental evolution for the recovery of growth loss due to genome reduction

    Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
    Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
    1. Genetics and Genomics

    Mono-methylated histones control PARP-1 in chromatin and transcription

    Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin
    Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
    1. Structural Biology and Molecular Biophysics

    A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation

    Xiao-Ru Chen, Karuna Dixit ... Tatyana I Igumenova
    Integrated biophysical, structural, and in-cell approaches demonstrate a non-canonical and non-isomerizable binding motif-dependent mode of protein kinase C regulation by the peptidyl-prolyl isomerase Pin1 in mammalian cells.