Browse our Research Articles

Page 227 of 1,392
    1. Developmental Biology
    2. Neuroscience

    Lmx1a is a master regulator of the cortical hem

    Igor Y Iskusnykh, Nikolai Fattakhov ... Victor V Chizhikov
    LIM-homeodomain transcription factor Lmx1a co-regulates multiple developmental processes in the cortical hem, a major signaling center necessary for hippocampus formation in the mammalian brain.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Epigenetic signature of human immune aging in the GESTALT study

    Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci
    Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
    1. Neuroscience

    Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

    Sydney M Bailes, Daniel EP Gomez ... Laura D Lewis
    The frequency content of resting-state fMRI signals contains information that can characterize and predict local variations in hemodynamic response timing which enhances the temporal precision of fMRI.
    1. Cell Biology

    BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    Zhiwang Zhang, Qichao Liao ... Lei Zhou
    Gene function studies confirmed that the BATF-PD1 axis and BATF-IL27 axis are regulatory factor for lipid accumulation in hepatocytes and adipocytes.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

    Jenny van Dongen, Gonneke Willemsen ... Michael C Neale
    Analysis of data from monozygotic twins reveals that DNA methylation level in human blood cells is reactive to cigarette smoking.
    1. Microbiology and Infectious Disease

    Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis

    Somnath Shee, Reshma T Veetil ... Amit Singh
    Genome-scale integration of transposon mutagenesis with a redox biosensor identified a hypothetical transcription factor- Rv0158 required to calibrate the growth, cytoplasmic redox potential, and respiration of Mycobacterium tuberculosis in response to metabolic switching from glucose to fatty acids.
    1. Biochemistry and Chemical Biology

    A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

    Magnus Chan, Harutyun Sahakyan ... David Fedida
    Characterization of an extra-membrane site in IKs formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.
    1. Evolutionary Biology

    An armoured marine reptile from the Early Triassic of South China and its phylogenetic and evolutionary implications

    Andrzej S Wolniewicz, Yuefeng Shen ... Jun Liu
    A new fossil sheds light on the evolution of an aquatic lifestyle in extinct reptiles and supports a close phylogenetic relationship between archosaurs (crocodiles, dinosaurs, birds, and kin) and turtles.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

    Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft
    Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
    1. Computational and Systems Biology

    A hierarchical model for external electrical control of an insect, accounting for inter-individual variation of muscle force properties

    Dai Owaki, Volker Dürr, Josef Schmitz
    A near-linear relationship between electrical stimulus duration and resultant joint torque in stick insects has been unveiled, enhancing control strategies in biohybrid robotics.