Excitatory and inhibitory neurons in the mouse superior colliculus receive comparably strong inputs from retinal ganglion cells, in contrast to the thalamocortical system.
The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.
CaMKII and the actin-crosslinking protein α-actinin-2 associate within minutes of the induction of long-term potentiation and disrupting this interaction prevents formation of enlarged dendritic spines.
David J Bacsik, Bernadeta Dadonaite ... Jesse D Bloom
Quantification of both viral transcription and progeny production from single influenza-infected cells shows that the cells that produce the most viral RNA often do not produce the most virions.
ECM-Itgb1 signaling and cell-cell adhesion are pivotal and coordinate together to regulate pancreatic islet aggregation, architecture, and functional maturation during development.
The balanced utilization of energy sources, namely carbohydrates and fats, by mitochondria, is critically important for the long-term maintenance of both skeletal muscle and heart health.
The initiation of DNA damage checkpoint recovery involves ATM-mediated E3 ubiquitin ligase E6AP phosphorylation which disrupts E6AP-MASTL association and leads to MASTL protein accumulation and cell cycle resumption.
Andreas Berghaenel, Jeroen MG Stevens ... Verena Behringer
Scaling laws reveal the presence of adolescent growth spurts in bonobos and potentially in other non-human primates, challenging the notion of these spurts as a uniquely human trait and emphasizing the need to consider scaling laws when interpreting growth patterns.
