Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
Imprecision in decoding information and swap error, that is, mistakenly reporting a non-target feature, contributes to working memory deficit in the multiple sclerosis population.
Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
Patrik Simmler, Eleonora I Ioannidi ... Gerald Schwank
SF3B1-K700E, a gene mutaiton found recurrently mutated in pancreatic cancer, increases malignancy in an autochthonous mouse model of pancreatic cancer and induces resistance against TGF-β-induced apoptosis in vitro by missplicing of MAP3K7.
Denis Dacheux, Guillaume Martinez ... Charles Coutton
Bi-allelic mutations in ZMYND12, encoding a novel axonemal protein interacting with TTC29 and DNAH1, cause male infertility and flagellum defects in human and Trypanosoma.
High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks
The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.
TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.
A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.
Basil T Thommen, Jerzy M Dziekan ... Nicolas MB Brancucci
Knocking out the FK506-binding protein in Plasmodium falciparum (PfFKBP35) affects ribosome homeostasis and results in a delayed death-like phenotype that is independent of the mode of action of FK506.