Browse our Research Articles

Page 238 of 1,418
    1. Neuroscience

    A mechanistic insight into sources of error of visual working memory in multiple sclerosis

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Imprecision in decoding information and swap error, that is, mistakenly reporting a non-target feature, contributes to working memory deficit in the multiple sclerosis population.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

    Vivian Chen, Milo S Johnson ... Gavin Sherlock
    Pleiotropy of adaptive clones isolated from diverse experimental environment.
    1. Cancer Biology

    Mutant SF3B1 promotes malignancy in PDAC

    Patrik Simmler, Eleonora I Ioannidi ... Gerald Schwank
    SF3B1-K700E, a gene mutaiton found recurrently mutated in pancreatic cancer, increases malignancy in an autochthonous mouse model of pancreatic cancer and induces resistance against TGF-β-induced apoptosis in vitro by missplicing of MAP3K7.
    1. Genetics and Genomics

    Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

    Denis Dacheux, Guillaume Martinez ... Charles Coutton
    Bi-allelic mutations in ZMYND12, encoding a novel axonemal protein interacting with TTC29 and DNAH1, cause male infertility and flagellum defects in human and Trypanosoma.
    1. Computational and Systems Biology
    2. Ecology

    100 years of anthropogenic impact causes changes in freshwater functional biodiversity

    Niamh Eastwood, Jiarui Zhou ... Luisa Orsini
    High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
    1. Chromosomes and Gene Expression

    ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes

    Danielle J Owen, Elisa Aguilar-Martinez ... Andrew D Sharrocks
    The transcriptional regulator ZMYM2 homes to distinct classes of retrotransposons bound by the TRIM28 and ChAHP chromatin complexes in human cells, which is broadly relevant in the transcriptional regulation field.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

    Sahla Syed, Yifei Duan, Bomyi Lim
    TF-DNA binding regulates spatial and temporal gene expression and drives robust pattern formation by modulating transcriptional kinetics via cooperative interactions among weak TF binding sites and tuning bursting rates by reducing the time spent in the ON state.
    1. Stem Cells and Regenerative Medicine

    An in vitro model for vitamin A transport across the human blood–brain barrier

    Chandler B Est, Regina M Murphy
    A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.
    1. Microbiology and Infectious Disease

    Genetic validation of PfFKBP35 as an antimalarial drug target

    Basil T Thommen, Jerzy M Dziekan ... Nicolas MB Brancucci
    Knocking out the FK506-binding protein in Plasmodium falciparum (PfFKBP35) affects ribosome homeostasis and results in a delayed death-like phenotype that is independent of the mode of action of FK506.