Browse our Research Articles

Page 242 of 1,485
    1. Neuroscience

    Representational drift as a result of implicit regularization

    Aviv Ratzon, Dori Derdikman, Omri Barak
    Continuous noisy learning in neural networks leads to slow, directed qualitative changes in their internal representations, without affecting their quality.
    1. Microbiology and Infectious Disease

    Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

    Michael D Sacco, Lauren R Hammond ... Yu Chen
    The N-terminal domain of Staphylococcus aureus GpsB, a scaffolding protein, forms an atypical asymmetric dimer and binds to the C-termini of FtsZ and PBP4, influencing the localization and regulation of both the Z-ring and cell wall synthesis.
    1. Cell Biology

    BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

    Ruichen Yang, Hongshang Chu ... Baojie Li
    Uncovering a new function of BMP signaling and enhancing our comprehension of the pathogenesis of microtia.
    1. Medicine

    Fungal–bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

    Peigen Chen, Haicheng Chen ... Xing Yang
    Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Experimental evolution for the recovery of growth loss due to genome reduction

    Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
    Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
    1. Genetics and Genomics

    Mono-methylated histones control PARP-1 in chromatin and transcription

    Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin
    Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
    1. Structural Biology and Molecular Biophysics

    A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation

    Xiao-Ru Chen, Karuna Dixit ... Tatyana I Igumenova
    Integrated biophysical, structural, and in-cell approaches demonstrate a non-canonical and non-isomerizable binding motif-dependent mode of protein kinase C regulation by the peptidyl-prolyl isomerase Pin1 in mammalian cells.
    1. Cancer Biology
    2. Cell Biology

    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

    Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan
    TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.
    1. Neuroscience

    Aberrant cortical activity, functional connectivity, and neural assembly architecture after photothrombotic stroke in mice

    Mischa Vance Bandet, Ian Robert Winship
    Longitudinal calcium imaging in awake mice after stroke suggests impairments in neuronal activity, functional connectivity, and neural assembly architecture is transient and limited to cortex immediately adjacent to the stroke.
    1. Microbiology and Infectious Disease

    Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

    Magdalena Podkowik, Andrew I Perault ... Bo Shopsin
    A new framework for examining tolerance in the context of quorum-sensing that may ultimately help predict and manage bacterial tolerance and, therefore, improve clinical outcome during infection.