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A genetic screen identifies a lipid pathway which impacts the endoplasmic reticulum unfolded protein response and highlights a mechanism through which lipid disequilibrium might facilitate the progression of proteopathic diseases.

The dorsal telencephalon (pallium) in medaka fish accommodates an epigenetically distinct brain area that selectively regulates unique set of synaptic genes compared to the surrounding pallial region, providing insights into the evolution of the pallium in vertebrate.

Modeling the dynamics of immunological synapses informs pharmacodynamics and treatment resistance to bispecific T cell engagers.

A nonspecific cation current mediated by TRPM4 channels is a major contributor to the increase in excitability induced by cholinergic modulation in hippocampal CA1 pyramidal neurons, which are thought to play an important role in episodic memory.

Studies in mice and neurons reveal how modulation of the axonal transport of synaptic vesicles via huntingtin phosphorylation influences the number of vesicles accumulating at the synapse, subsequent glutamate release, and behavior in mice.

Shifting from girls-only to gender-neutral HPV vaccination strategy improves the resilience of cervical cancer prevention and enhances progress towards cervical cancer elimination.

A multiplexed microfluidic device was developed to facilitate high-throughput screening of bacterial chemotaxis on a single chip and demonstrated across a range of microbes, chemostimulants, and chemical gradient conditions.

Profiling spatially defined fibroblasts in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment identifies high levels of podoplanin and hypoxia in tumor-proximal fibroblasts associated with bad prognosis, whilst inflammatory markers define more distal fibroblast regions and associate with better outcomes.

Genes of the MICOS complex are a major candidate pathway to be potentially linked to defects in cardiomyocyte growth and differentiation in Hypoplastic left heart syndrome (HLHS), and relevant for elucidating the polygenic nature of HLHS and other CHDs.

Proteins locked into the immature HIV lattice can exploit its incomplete structure to form the essential protease dimer needed for viral maturation.