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Experimental manipulations and a mechanical model of the fiber reveal that the Reissner fiber is under heterogenous tension in vivo, and interacts with the motile cilia of diverse cells contacting the cerebrospinal fluid.

Dysmyelination of GABAergic hippocampal interneurons causes mislocalization of axonal ionic channels and disturbs their intrinsic physiological properties, suggesting that it may contribute to cognitive deficits observed in multiple sclerosis patients.

A computational neuroanatomy analysis of cerebellar and cerebral folding in 56 mammalian species reveals groups of highly variable 'diverse' phenotypes, and strongly conserved 'stable' phenotypes, providing new insights into the diversity, evolution, and influence of cortical folding on brain organisation.

Live cell tracking of labeled DNA reveals that replisome loading rather than DNA synthesis decreases the chromatin motion during S-phase in human cells.

Cryo-EM, Molecular Dynamics, and in vitro binding assays are combined to elucidate a new occluded conformation associated with zinc binding and energy coupling with the proton motive force.

A novel therapy for a common blinding retinal disease uses an innovative CCR1 blocking-based strategy.

The archetypal tumor promoter PMA, which promotes cancer without mutating the DNA, increases Wnt signaling by activating macropinocytosis and membrane trafficking in Xenopus embryos and tumor cells.

Acetate concentration, which is significantly increased in association with energy stresses such as those that occur with diabetes or starvation, is emerging as a novel 'ketone body' with potential as a parameter for evaluating the progression of energy stress.

Developing eggs and sperm differentially regulate specific steps of meiotic DNA repair by altering the composition and dynamics of proteins within synaptonemal complex.

Advanced glycation end-products (compounds which make the food appetizing and aromatic) intricately modulate organism’s homeostatic and hedonistic signaling pathways thereby inducing preferential consumption of excess nutrients offering preliminary insights into overconsumption of modern-day processed food.