Browse our Research Articles

Page 259 of 1,392
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

    Sofia Gomez, Lionel Bureau ... Sigolene Lecuyer
    The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Epidemiology and Global Health

    Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data

    Margarita Pons-Salort, Ben Lambert ... Nicholas C Grassly
    Serocatalytic models applied to seroprevalence data from England reveal an increase in Enterovirus D68 transmission that occurred before 2011.
    1. Cell Biology
    2. Neuroscience

    Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain

    Elizabeth L Wagner, Jun-Sub Im ... Jung-Bum Shin
    A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.
    1. Microbiology and Infectious Disease

    Homeostatic control of an iron repressor in a GI tract resident

    Yuanyuan Wang, Yinhe Mao ... Changbin Chen
    Post-translational modifications of an iron-responsive regulator drive Candida albicans commensalism in gastrointestinal tract.
    1. Chromosomes and Gene Expression

    Identification of epigenetic modulators as determinants of nuclear size and shape

    Andria C Schibler, Predrag Jevtic ... Tom Misteli
    Chromatin modifiers shape nuclear morphology.
    1. Cancer Biology

    The CD73 immune checkpoint promotes tumor cell metabolic fitness

    David Allard, Isabelle Cousineau ... John Stagg
    Targeting CD73 not only enhances anti-tumor immunity but also disrupts tumor cell metabolism and hinders poly ADP ribose polymerase (PARP) activity, thus unveiling novel opportunities for combination cancer treatments.
    1. Genetics and Genomics

    Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning

    Gemma E May, Christina Akirtava ... Joel McManus
    The regulatory role of thousands of upstream open-reading frames were measured and used to determine the relative influences of sequence, structural, and positional features on translation regulation and nonsense-mediated decay.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

    Abderrahman Hachani, Stefano G Giulieri ... Timothy P Stinear
    Staphylococcus aureus switches from innocuous coloniser to invasive human pathogen, the bacterial population can accumulate pathoadaptive mutations that reduce bacterial toxicity whilst allowing persistence within infected cells, potentially leading to severe human infections.
    1. Developmental Biology
    2. Computational and Systems Biology

    Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor

    Erik S Schild, Shivam Gupta ... Hendrik C Korswagen
    Robust temporal regulation of a developmental decision in migrating Caenorhabditis elegans neuroblasts is mediated through a strategy that combines transcriptional activation and feedback of a timekeeper gene.