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A multiplexed microfluidic device was developed to facilitate high-throughput screening of bacterial chemotaxis on a single chip and demonstrated across a range of microbes, chemostimulants, and chemical gradient conditions.

Profiling spatially defined fibroblasts in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment identifies high levels of podoplanin and hypoxia in tumor-proximal fibroblasts associated with bad prognosis, whilst inflammatory markers define more distal fibroblast regions and associate with better outcomes.

Genes of the MICOS complex are a major candidate pathway to be potentially linked to defects in cardiomyocyte growth and differentiation in Hypoplastic left heart syndrome (HLHS), and relevant for elucidating the polygenic nature of HLHS and other CHDs.

Proteins locked into the immature HIV lattice can exploit its incomplete structure to form the essential protease dimer needed for viral maturation.

Maturation of light-sensitive 'disc' membranes in vertebrate photoreceptors requires a precise balance between their content of the visual pigment rhodopsin forming the disc body and tetraspanin proteins forming the disc rim.

Consistent with an existing computational model of hippocampal function, using real-time feedback to drive artificial memories at the trough of the hippocampal theta rhythm improves apparent recall.

The functional role of novel regulatory mechanism within prototypic oncogenic kinase c-Src is described with particular emphasis on cancer cell migration, invasiveness, oncogenic transformation, and multilevel regulation of Src itself.

New evidence of brain proinflammatory cascades supports post-acute sequelae of SARS-CoV-2 infection, ultimately promoting the onset and progression of Alzheimer's disease as a function of age.

To isolate and study proprioception, hierarchical deep neural networks paired with biomechanical models provide a normative approach to test the role of task effects on neural representations, such as the emergence of kinematic tuning and higher-level abstractions of actions.

Zebrafish have a physiological time-window of 1 hr for breaking left-right symmetry and are highly sensitive to the left-right organizer anterior fluid mechanics rather than to the nature of its fluid content.