Browse our Research Articles

Page 356 of 1,392
    1. Evolutionary Biology

    Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata

    Tuomas Hämälä, Weixuan Ning ... Outi Savolainen
    Environmentally responsive genes evolve under strong selective constraint in Arabidopsis lyrata.
    1. Developmental Biology

    Regulation of Nodal signaling propagation by receptor interactions and positive feedback

    Hannes Preiß, Anna C Kögler ... Patrick Müller
    A subset of the zebrafish Nodal receptor complex is regulated by positive feedback and controls the diffusion and distribution of Nodal signals during germ layer formation.
    1. Cell Biology

    Tumor elimination by clustered microRNAs miR-306 and miR-79 via noncanonical activation of JNK signaling

    Zhaowei Wang, Xiaoling Xia ... Tatsushi Igaki
    miR-306 and miR-79 selectively eliminate JNK-activated tumors, providing a new microRNA-based strategy against cancer.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Excitatory and inhibitory D-serine binding to the NMDA receptor

    Remy A Yovanno, Tsung Han Chou ... Albert Y Lau
    Molecular dynamics simulations reveal that D-serine competes with glutamate for binding to the NMDA receptor, a finding supported by electrophysiology experiments with consequences for D-serine-focused therapeutic strategies for myriad neurological disorders.
    1. Medicine
    2. Microbiology and Infectious Disease

    Novel fast pathogen diagnosis method for severe pneumonia patients in the intensive care unit: randomized clinical trial

    Yan Wang, Xiaohui Liang ... Wenkui Yu
    A novel species-specific detection method could obtain pathogenic bacteria information in 4 hr with high clinical sensitivity and specificity, which guided the faster antibiotic treatment in ICU and brought some clinical benefit in a real-world scenario.
    1. Neuroscience

    Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors

    Florian Aymanns, Chin-Lin Chen, Pavan Ramdya
    In the fly, Drosophila melanogaster, the population activity of descending neurons (DNs) projecting from the brain to the motor system is predominantly correlated with locomotion with only a few DNs encoding grooming or olfactory signals in the absence of behavior.
    1. Cell Biology
    2. Neuroscience

    KLC4 shapes axon arbors during development and mediates adult behavior

    Elizabeth M Haynes, Korri H Burnett ... Mary C Halloran
    Newly identified roles for the kinesin-1 light chain subunit KLC4 in patterning developing axon arbors, regulating microtubule dynamics and influencing behavior of larval and adult zebrafish.
    1. Ecology
    2. Genetics and Genomics

    Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure

    Samuel E Champer, Isabel K Kim ... Jackson Champer
    Continuous space models indicate that current homing suppression drives may have difficulty eliminating wild mosquito populations, but building a successful drive may still be possible with current tools.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

    Oliver Stirrup, James Blackstone ... Judith Breuer
    Sequencing of viral genomes could be useful for infection prevention and control within hospitals, but did not lead to a reduction in the rate of hospital-acquired SARS-CoV-2 infections over winter 2020/2021 in a large multicentre UK study.
    1. Developmental Biology
    2. Neuroscience

    Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

    Emeric Merour, Hatem Hmidan ... Carlos Parras
    A comprehensive analysis of Tensin3 function in oligodendrogenesis links the fields of transcriptional control in oligodendrocyte lineage cells with morphogenetic changes and integrin signaling mediated cell survival.