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The humoral and cellular immune responses were evaluated for two immunization schedules for the inactivated SARS-CoV-2 vaccine, CoronaVac, with two doses separated by 2 or 4 weeks, showing that these responses are mostly similar, with differences in neutralization capacities.

AIDPS derived by 76 machine-learning algorithm combinations in 13 independent multicenter cohorts exhibited superior capability than clinical traits and 86 published prognostic signatures and could serve as an ideal biomarker for stratified management and individualized treatment of pancreatic cancer.

The combination of mosquito transgenesis with paratransgenesis provides maximum parasite-blocking activity and has high potential for fighting malaria.

The immune system in the vagina becomes more active when young women begin to have sexual intercourse, and this immune activity could influence the risk of acquiring sexually transmitted infections.

Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.

The activation of defence brain circuits drives decisions to help conspecifics under threat.

Conditional knockout mice revealed that oxytocin secretion from the paraventricular hypothalamic nucleus suppresses hyperphagic obesity partly via the oxytocin receptor expressed in the arcuate hypothalamic nucleus.

In a large discrete choice experiment, respondents from six European countries reveal preferences for global vaccine solidarity, where female, younger, more educated respondents are most likely to prioritise candidates from the Global South in their allocation choices for COVID-19 vaccines.

The role of Isthmin-1 in muscle function is defined by using phosphoproteomics to identify distinct and overlapping signaling pathways between Isthmin-1 and insulin.

The structure of the yeast HOPS tethering complex suggests how this large complex may catalyze fusion by tethering Rab-decorated membranes and promoting the assembly of SNAREs.