Browse our Research Articles

Page 360 of 1,410
    1. Genetics and Genomics

    R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

    Kenichi Nagano, Kei Yamana ... Roland Baron
    R-spondin3 global haplo-insufficiency or its deletion in pre-osteoblasts lead to gain of bone mass in the appendicular skeleton with no or opposite phenotype in the axial skeleton.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Acetylation of a fungal effector that translocates host PR1 facilitates virulence

    Jingtao Li, Xiaoying Ma ... Wenxing Liang
    Acetylation stabilizes a fungal effector to mis-localize a key defense protein, leading to compromised immunity of host plants.
    1. Chromosomes and Gene Expression

    Mcm2 promotes stem cell differentiation via its ability to bind H3-H4

    Xiaowei Xu, Xu Hua ... Zhiguo Zhang
    Mcm2 promotes mouse embryonic stem cells differentiation through manipulating chromatin landscapes at bivalent chromatin domains.
    1. Genetics and Genomics
    2. Neuroscience

    Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila

    Justin A Bosch, Berrak Ugur ... Norbert Perrimon
    Sloth1 and Sloth2 are two mitochondrial peptides that are translated from one transcript and are important for neuronal function in Drosophila.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans

    Amy L Roberts, Alessandro Morea ... Kerrin S Small
    Prospective, cross-sectional, and intra-twin study designs identify skewed X chromosome inactivation is associated with cardiovascular disease risk and future cancer diagnosis in the TwinsUK population cohort.
    1. Structural Biology and Molecular Biophysics

    Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

    Alberto Borsatto, Obaeda Akkad ... Francesco Luigi Gervasio
    A combination of simulations and experiments was used to discover druggable cryptic pockets in non-structural protein 1, a promising but difficult target for coronaviruses, indicating a viable drug discovery approach for otherwise undruggable targets.
    1. Ecology

    Bundling and segregation affect pheromone deposition, but not choice, in an ant

    Massimo De Agrò, Chiara Matschunas, Tomer J Czaczkes
    Ants are subjected to logarithmic value perception, causing deviation from pure rationality as described by classical economics decision theories.
    1. Medicine

    Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron variant of concern

    Fulvia Mazzaferri, Massimo Mirandola ... Evelina Tacconelli
    Compared with casirivimab/imdevimab and bamlanivimab/etesevimab, early treatment with sotrovimab seems to reduce the time to sustained recovery among adult outpatients with mild-to-moderate SARS-CoV-2 infection due to Omicron BA.1 and BA.1.1.
    1. Cancer Biology

    Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

    James Boot, Gabriel Rosser ... Silvia Marino
    A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.
    1. Neuroscience

    Learning-related contraction of gray matter in rodent sensorimotor cortex is associated with adaptive myelination

    Tomas Mediavilla, Özgün Özalay ... Daniel J Marcellino
    Learning produces dynamic white matter volumetric changes in the rodent brain observed by voxel-based morphometry on longitudinal structural MRI for which estimated white matter volume reflects adaptive myelination in the cortex.