Browse our Research Articles

Page 361 of 1,392
    1. Microbiology and Infectious Disease

    LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

    M Julhasur Rahman, Sherry L Haller ... Stefan Rothenburg
    A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.
    1. Cell Biology
    2. Immunology and Inflammation

    Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning

    Nuno GB Neto, Sinead A O'Rourke ... Michael G Monaghan
    Human blood derived macrophage polarisation can be classified by proxy of their metabolism, using advanced microscopy techniques generating single-cell parameters that are clustered and validated using machine learning classification models.
    1. Computational and Systems Biology
    2. Medicine

    Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

    Lilija Wehling, Liam Keegan ... Kai Breuhahn
    Nuclear phosphorylation differentially controls the activity of Hippo pathways effectors YAP and TAZ via distinct molecular mechanisms under physiological and tissue damage conditions.
    1. Cell Biology
    2. Developmental Biology

    Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration

    Audrey Miller Williams, Seth Donoughe ... Sally Horne-Badovinac
    Fat2 signals from the trailing edge of each cell to localize WAVE activity to the leading edge of the cell behind, polarizing protrusive regions within cells and across the epithelium.
    1. Cell Biology

    Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

    Jill T Kuwabara, Akitoshi Hara ... Michelle D Tallquist
    Cardiac fibroblast reduction is well-tolerated and demonstrates beneficial outcomes after heart injury.
    1. Cell Biology

    Telocytes regulate macrophages in periodontal disease

    Jing Zhao, Anahid A Birjandi ... Paul Sharpe
    A poorly understood cell type, the telocyte, is shown to regulate macrophages.
    1. Neuroscience

    Balance between breadth and depth in human many-alternative decisions

    Alice Vidal, Salvador Soto-Faraco, Rubén Moreno-Bote
    A novel experimental paradigm investigating how humans manage limited search capacity over many alternatives reveals close-to-optimal behaviours and identifies heuristics used to minimize computation with little impact on performance.
    1. Epidemiology and Global Health

    Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries

    Xinxuan Li, Yajing Zhou ... Xue Li
    Genetically predicted high insulin-like growth factor levels may decrease the risk of COVID-19 susceptibility and hospitalization.
    1. Genetics and Genomics

    Fat body phospholipid state dictates hunger-driven feeding behavior

    Kevin P Kelly, Mroj Alassaf ... Akhila Rajan
    Behavioral, lipidomic, and genetic analyses of adult Drosophila on a chronic high-sugar regime identified that fat body activity of a phospholipid biosynthesis enzyme, Pect, regulates insulin sensitivity and hunger response.
    1. Chromosomes and Gene Expression

    The SPARC complex defines RNAPII promoters in Trypanosoma brucei

    Desislava P Staneva, Stefan Bresson ... Robin C Allshire
    The SPARC complex directs accurate RNAPII positioning for transcription initiation and, in some instances, ensures correct transcription directionality in Trypanosoma brucei.