Browse our Research Articles

Page 363 of 1,459
    1. Ecology
    2. Evolutionary Biology

    The deep-rooted origin of disulfide-rich spider venom toxins

    Naeem Yusuf Shaikh, Kartik Sunagar
    A remarkable case of the common evolutionary origin of a prominent spider venom component.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

    Flora Mikaeloff, Marco Gelpi ... Ujjwal Neogi
    Multi-omics-driven patient stratification identify at-risk profile of metabolic complications in people living with HIV on suppressive therapy that need clinical attention.
    1. Structural Biology and Molecular Biophysics

    Conserved allosteric inhibition mechanism in SLC1 transporters

    Yang Dong, Jiali Wang ... Christof Grewer
    Functional and computational studies reveal that the allosteric inhibition mechanism is conserved between glutamate and neutral amino acid transporters of the SLC1 family, and identify a novel allosteric inhibitor.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis

    Shuai Yuan, Jie Chen ... Susanna C Larsson
    Smoking is a risk factor for a broad range of gastrointestinal diseases independent of alcohol consumption.
    1. Cell Biology

    Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia

    Mitsugu Shimobayashi, Amandine Thomas ... Michael N Hall
    A proteomics screening in mouse adipose tissue shows that loss of adipose Hexokinase 2 is a mechanism of obesity-induced insulin insensitivity.
    1. Microbiology and Infectious Disease

    Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota

    Daniel Hoces, Giorgia Greter ... Emma Slack
    Neutral tagging and detailed analysis of bacterial growth kinetics can quantify the mechanisms of colonization resistance in differently colonized animals.
    1. Neuroscience

    Molecular and spatial profiling of the paraventricular nucleus of the thalamus

    Claire Gao, Chiraag A Gohel ... Mario A Penzo
    Molecular and spatial profiling methods idenified five neuronal subtypes that are distributed along the anteroposterior axis of the paraventricular thalamus, a structure increasingly implicated in the control of emotional and motivated behaviors.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Limited role of generation time changes in driving the evolution of the mutation spectrum in humans

    Ziyue Gao, Yulin Zhang ... Priya Moorjani
    A new framework for mutation spectrum analysis reveals multiple independent changes in the germline mutation patterns of human populations, which cannot be explained by shifts in average ages at reproduction.
    1. Physics of Living Systems

    Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

    Rachel A Banks, Vahe Galstyan ... Rob Phillips
    Mesoscopic properties of motor-microtubule assemblies, such as contractile rates and length scales, can be quantitatively connected to single-motor properties of kinesin motors.
    1. Cell Biology
    2. Computational and Systems Biology

    Information transfer in mammalian glycan-based communication

    Felix F Fuchsberger, Dongyoon Kim ... Christoph Rademacher
    The information stored in glycans is interpreted and read by cell surface-exposed lectin receptors, and with information theory, the formal framework is set for how to analyze such complex single-cell data.