Browse our Research Articles

Page 364 of 1,392
    1. Immunology and Inflammation

    Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells

    Małgorzata Anna Cichoń, Karin Pfisterer ... Adelheid Elbe-Bürger
    Reticulon 1A plays a central role not only in cytoskeletal remodeling of resident Langerhans cells but also in their clustering upon Toll-like receptor activation in human skin, suggesting an important role in maintaining tissue homeostasis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand-induced shifts in conformational ensembles that describe transcriptional activation

    Sabab Hasan Khan, Sean M Braet ... C Denise Okafor
    Transcriptional activity is characterized for five steroid receptors complexed with multiple ligands and it is shown that the extent of transcriptional activation in complexes is accurately described by conformational shifts in computationally-generated ensembles.
    1. Computational and Systems Biology

    A model-based analysis of the health impacts of COVID-19 disruptions to primary cervical screening by time since last screen for current and future disruptions

    Emily A Burger, Inge MCM de Kok ... Megan A Smith
    Despite the overall impact of COVID-19-related cervical cancer screening disruptions on cervical cancer outcomes being small, disruptions disproportionately affect underscreened women, underpinning the importance of reaching such women as a critical area of focus, regardless of temporary disruptions.
    1. Developmental Biology
    2. Neuroscience

    Plexins promote Hedgehog signaling through their cytoplasmic GAP activity

    Justine M Pinskey, Tyler M Hoard ... Benjamin L Allen
    The plexin family of semaphorin receptors regulate Hedgehog pathway activity via a conserved GAP domain and FYN kinase phosphorylation site in their cytoplasmic domain.
    1. Cancer Biology
    2. Medicine

    Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindow

    Yihui Gu, Zhichao Wang ... Qingfeng Li
    In vivo and in vitro experiments confirm the conspicuous antineoplastic efficacy of NIR-III photothermal therapy under the premise of ensuring biosafety.
    1. Stem Cells and Regenerative Medicine

    Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

    Justinn Barr, Maria Elena Gentile ... Andrew E Vaughan
    Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

    Huachao Huang, Yinshan Fang ... Jianwen Que
    A population of p63+ Krt5- epithelial cells contribute to alveolar regeneration independent of the presence of ectopic tuft cells following viral infection.
    1. Ecology
    2. Plant Biology

    Rapid transgenerational adaptation in response to intercropping reduces competition

    Laura Stefan, Nadine Engbersen, Christian Schöb
    Annual crop communities are able to adapt towards reduced competition and/or increased facilitation in response to their neighboring diversity after only two generations.
    1. Evolutionary Biology

    Novel multicellular prokaryote discovered next to an underground stream

    Kouhei Mizuno, Mais Maree ... Kazuya Morikawa
    A new bacterium isolated from an underground stream shows a novel multicellularity by self-organizing its filamentous cells like a liquid crystal and accommodating daughter cells in a sequential manner, which would be a new extant model of prokaryotic multicellularity.
    1. Medicine

    Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

    Alba Navarro-Romero, Lorena Galera-López ... Andres Ozaita
    A mouse model of Williams–Beuren syndrome allowed us to assess the endocannabinoid system and the impact of targeting the monoacyl glycerol lipase in modulating key phenotypes such as cognitive and hypersocial phenotype as well as the cardiac phenotype.