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The amination network for the distribution of assimilated ammonium throughout metabolism is defined by promiscuous transaminases, allowing a high flexibility of the network that supported engineering novel connections and even alternative ammonium assimilation entry points.

The yeast U1 snRNP recognizes multiple features of target RNAs to reversibly identify splicing-competent 5' splice sites.

After DNA damage induction, transcription is blocked and XAB2 is released from R-loops allowing a subset of XAB2 molecules to interact with UV-stalled RNAP2 and participating to the TC-NER process.

The cAMP sensor and effector Epac2 facilitates dopamine release and promotes cocaine reward.

Structural basis and molecular mechanism of how molecular chaperone Hsp27 specifically captures phosphorylated Tau and prevents it from abnormal aggregation.

Time-resolved phosphoproteomics and thermal proteome profiling reveal the Ca²⁺-responsive proteome of the model apicomplexan Taxoplasma gondii, identifying PP1 as a Ca²⁺-responsive enzyme that regulates Ca²⁺ uptake to promote parasite motility.

Closely related type II-C Cas9 orthologs recognize diverse PAMs, which facilitates us to expand the targeting scope.

The pentameric condensin II complex is equipped with a multilayered, self-regulatory mechanism that supports mitotic chromosome assembly.

Structure of M. tuberculosis Rv1625c/Cya provides clues to the potential functional role of the transmembrane domain in the membrane adenylyl cyclases.

Satellite glia provide trophic support to adult sympathetic neurons and modulate neuronal activity and autonomic function in mice.