Browse our Research Articles

Page 419 of 1,394
    1. Evolutionary Biology

    Squamation and scale morphology at the root of jawed vertebrates

    Yajing Wang, Min Zhu
    New morphological data of a primitive placoderm fish demonstrate both high regionalization of squamation and the bipartite histological structure of scale are plesiomorphic for jawed vertebrates.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

    Eriko Matsuura-Suzuki, Tadahiro Shimazu ... Shintaro Iwasaki
    METTL18 methylates histidine 245 of ribosomal protein RPL3, retards ribosome traversal at tyrosine codons, and thus ensures nascent protein folding for proteostasis maintenance.
    1. Neuroscience

    Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells

    Kevin Beier
    A modified viral strategy reveals that ventral tegmental area dopamine cells receive substantial inputs from local sources, including distributed GABAergic and serotonergic inputs from the midbrain as well as extensive inputs from other midbrain dopamine cells.
    1. Neuroscience

    Conditional and unconditional components of aversively motivated freezing, flight and darting in mice

    Jeremy M Trott, Ann N Hoffman ... Michael S Fanselow
    When conducting fear conditioning in mice, cue-elicited activity bursts are primarily a result of nonassociative processes, and freezing behavior remains the best index for associative learning.
    1. Developmental Biology
    2. Neuroscience

    A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian

    Eleni Chrysostomou, Hakima Flici ... Uri Frank
    SoxB genes are sequentially expressed in cnidarian neurogenesis.
    1. Cell Biology
    2. Medicine

    Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

    Vinciane Saint-Criq, Anita Guequén ... Carlos A Flores
    The reduction of bicarbonate secretion into the airways reproduces cystic fibrosis-like features, independently of chloride secretion.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Fast bacterial growth reduces antibiotic accumulation and efficacy

    Urszula Łapińska, Margaritis Voliotis ... Stefano Pagliara
    Phenotypic variants that avoid antibiotic accumulation within clonal bacterial populations are a significant contributor to antibiotic treatment failure and can rely on previously unrecognised survival strategies such as fast growth during drug treatment.
    1. Neuroscience

    Drosophila gustatory projections are segregated by taste modality and connectivity

    Stefanie Engert, Gabriella R Sterne ... Kristin Scott
    Anatomical and synaptic reconstructions of gustatory axons from the adult Drosophila labellum reveal different classes of gustatory neurons recognizing different taste modalities.
    1. Neuroscience

    Aberrant causal inference and presence of a compensatory mechanism in autism spectrum disorder

    Jean-Paul Noel, Sabyasachi Shivkumar ... Dora E Angelaki
    Individuals within the autism spectrum disorder implicitly outweigh integration (rather than segregating) when performing causal inference and have developed an explicit compensatory mechanism as reflected in choice biases.
    1. Genetics and Genomics
    2. Neuroscience

    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

    Junhao Li, Antonio Pinto-Duarte ... M Margarita Behrens
    Loss of Dnmt3a in excitatory neurons disrupts synaptic morphology and behavior, and triggers the expansion of H3K27me3 binding, suggestive of increased polycomb repression.