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Olfactory sensory neurons have centrioles that are amplified in number and that migrate from the cell body to the end of the dendrite relatively slowly and in groups, becoming mature only after they reach their destination.

Reward and information are independently optimized in the human prefrontal cortex, while their signals combine in subcortical regions.

State-of-the-art measurements of microtubule growth combined with computational models provide new insights into the molecular mechanisms underlying microtubule elongation, including a role for GDP on the growing microtubule end.

Xenopus embryos use tissue surface tension to generate hoop-stress around the blastopore to help close it during gastrulation.

Calsyntenin-3 functions in cerebellar Purkinje neurons as a postsynaptic adhesion molecule that, unexpectedly, suppresses excitatory parallel-fiber synapse numbers but boosts inhibitory synapse numbers and thereby controls the excitatory/inhibitory balance of Purkinje neurons.

Proteolytic cleavage of the extracellular matrix glycoprotein fibrillin-2 by the secreted metalloprotease ADAMTS6 influences skeletal development by modulating fibrillin microfibril abundance and GDF5/BMP signaling, illustrating the crucial role of extracellular matrix proteostatic mechanisms in growth factor regulation during morphogenesis.

Evidence for a largely unexplored radiation of squamates (lizards, snakes, and amphisbaenians) in the Middle to Late Jurassic is revealed by analyses of morphospace expansion, disparity, and evolutionary rates.

Oncoprotein BCL6 confers tumor adaptive resistance to genotoxic stress through the IFN-BCL6-PTEN axis in solid tumors and presents a promising combinational target for chemo-sensitization.

A novel population of adipocytes that play essential roles in adaptive thermogenesis via cell autonomous and non-autonomous effects and regulate systemic glucose metabolism in mice.

Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.