Browse our Research Articles

Page 48 of 1,406
    1. Biochemistry and Chemical Biology

    Induction of hepatitis B core protein aggregation targeting an unconventional binding site

    Vladimir Khayenko, Cihan Makbul ... Hans Michael Maric
    Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.
    1. Neuroscience

    Auditory cortex anatomy reflects multilingual phonological experience

    Olga Kepinska, Josue Dalboni da Rocha ... Narly Golestani
    Multilingual experience, particularly with larger phonological inventories across multilinguals’ languages, is linked to structural differences in transverse temporal gyri, highlighting experience-driven plasticity as a key factor shaping auditory cortex anatomy.
    1. Genetics and Genomics

    Reported transgenerational responses to Pseudomonas aeruginosa in Caenorhabditis elegans are not robust

    Daniel Patrick Gainey, Andrey V Shubin, Craig P Hunter
    The failure to replicate key findings from an important report on transgenerational inheritance in Caenorhabditis elegans raises concerns about the robustness and ecological significance of the previously reported results.
    1. Developmental Biology

    Opposing roles for Bmp signalling during the development of electrosensory lateral line organs

    Alexander S Campbell, Martin Minařík ... Clare VH Baker
    In sturgeon, fewer electrosensory organs form after targeting Bmp5 for CRISPR/Cas9-mediated mutagenesis, whereas more form after chemically blocking all Bmp signalling shortly before their primordia emerge, suggesting that Bmp signalling has opposing effects during electrosensory organ development.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland

    Gabriel Magno de Freitas Almeida, Iker Arriaga ... Lotta-Riina Sundberg
    Jyvaskylavirus, the northernmost isolate of the Marseilleviridae family, shows that giant viruses are also part of the boreal Finnish environment and brings structural information with relevance for understanding other viruses.
    1. Cell Biology

    Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex

    Jittoku Ihara, Yibin Huang ... Koichi Yamamoto
    Oxidized LDL synergizes with angiotensin II to amplify Gq signaling via the AT1-LOX1 receptor complex, revealing a novel mechanism driving renal dysfunction in hypertension and dyslipidemia.
    1. Cancer Biology

    In vivo targeted and deterministic single-cell malignant transformation

    Pierluigi Scerbo, Benjamin Tisserand ... Bertrand Ducos
    Oncogene permanent activation in a single targeted cell of zebrafish together with a reprogramming factor transient activation is sufficient to induce the malignant transformation of the cell and tumor development.
    1. Cell Biology
    2. Neuroscience

    Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease

    Vibhavari Aysha Bansal, Jia Min Tan ... Toh Hean Ch'ng
    Characterization of nuclear pore loss and dysfunction in nucleocytoplasmic compartmentalization in Alzheimer's disease neurons.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Loss of CTRP10 results in female obesity with preserved metabolic health

    Fangluo Chen, Dylan C Sarver ... G William Wong
    Mice lacking the secreted hormone, CTRP10, represent a unique female model of obesity with preserved metabolic health, highlighting sex-specific mechanisms that uncouple obesity from metabolic dysfunction.
    1. Neuroscience

    Spatial localization of hippocampal replay requires dopamine signaling

    Matthew R Kleinman, David J Foster
    Hippocampal replay, which is implicated in memory formation and planning, exhibits a reward-dependent spatial specificity that in novel environments requires dopamine signaling.