Browse our Research Articles

Page 487 of 1,390
    1. Cell Biology

    Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

    Emanuel Rognoni, Georgina Goss ... Fiona M Watt
    UV irradiation, a major cause of skin damage, leads to selective loss of fibroblasts from the upper dermis via a deregulated inflammatory response, and infiltrating T cells can promote fibroblast survival in UV irradiated skin.
    1. Epidemiology and Global Health

    3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

    Marius Reichardt, Patrick Moller Jensen ... Tim Salditt
    X-ray phase-contrast tomography reveals pathology of capillaries in heart tissue from patients who succumbed to Covid-19, as well as alterations in the three-dimensional cardiac tissue structure.
    1. Computational and Systems Biology
    2. Neuroscience

    The energetic basis for smooth human arm movements

    Jeremy D Wong, Tyler Cluff, Arthur D Kuo
    An energetic cost related to force rate is quantified in human arm movements, and minimizing this cost predicts smoothness without minimizing variance, unifies motor-planning of smoothness and movement duration, and may help resolve motor redundancies.
    1. Neuroscience

    The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx

    Luigi Prisco, Stephan Hubertus Deimel ... Gaia Tavosanis
    By participating in the microglomerular microcircuit in the Drosophila mushroom body calyx, the anterior paired lateral neuron normalizes odour-evoked representations at the calyx via inhibition proportional to the input strength and localized to the regions where those inputs are positioned.
    1. Cell Biology
    2. Evolutionary Biology

    Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

    Chirine Toufaily, Jérôme Fortin ... Daniel J Bernard
    The absence of a carboxy-terminal tail in the GnRH receptor is not required for the preovulatory luteinizing hormone surge and fertility in mammals.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

    Kenneth B Hoehn, Jackson S Turner ... Steven H Kleinstein
    Influenza vaccination in humans stimulates novel B cell evolution that is detectable in germinal centers, but not the peripheral blood.
    1. Evolutionary Biology

    Evolutionary footprints of a cold relic in a rapidly warming world

    Eva Wolf, Emmanuel Gaquerel ... Marcus A Koch
    Evolutionary dynamics of polyploid plants of the genus Cochlearia during past periods of rapid climate change indicate increased rates of speciation and diversification in response to pronounced glacial cycles and cold periods in particular.
    1. Structural Biology and Molecular Biophysics

    Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9

    Lukasz Nierzwicki, Kyle W East ... Giulia Palermo
    Allostery holds critical role in CRISPR-Cas9 specificity enhancement.
    1. Cancer Biology
    2. Computational and Systems Biology

    Quantitative analysis of tumour spheroid structure

    Alexander P Browning, Jesse A Sharp ... Matthew Simpson
    A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

    Dylan Gerard Ryan, Ming Yang ... Christian Frezza
    Multi-omic analyses reveal a connection between the integrated stress response and the regulation of redox and amino acid metabolism when the TCA cycle is impaired.