Super-resolution imaging uncovers sparse occludin vs. clustered ZO1/claudin-5 architecture, and claudin-5 arrangement compacting during blood-brain-barrier tight-junction (TJ) maturation in which TJs become first restrictive to large and later to small molecules.
Novel Cas9 fusion with DNA polymerase delta subunit 3 (POLD3), identified via high-throughput screening of more than 450 DNA repair proteins, enhances editing by speeding up the initiation of DNA repair.
UV irradiation, a major cause of skin damage, leads to selective loss of fibroblasts from the upper dermis via a deregulated inflammatory response, and infiltrating T cells can promote fibroblast survival in UV irradiated skin.
Marius Reichardt, Patrick Moller Jensen ... Tim Salditt
X-ray phase-contrast tomography reveals pathology of capillaries in heart tissue from patients who succumbed to Covid-19, as well as alterations in the three-dimensional cardiac tissue structure.
An energetic cost related to force rate is quantified in human arm movements, and minimizing this cost predicts smoothness without minimizing variance, unifies motor-planning of smoothness and movement duration, and may help resolve motor redundancies.
Luigi Prisco, Stephan Hubertus Deimel ... Gaia Tavosanis
By participating in the microglomerular microcircuit in the Drosophila mushroom body calyx, the anterior paired lateral neuron normalizes odour-evoked representations at the calyx via inhibition proportional to the input strength and localized to the regions where those inputs are positioned.
Evolutionary dynamics of polyploid plants of the genus Cochlearia during past periods of rapid climate change indicate increased rates of speciation and diversification in response to pronounced glacial cycles and cold periods in particular.
