Browse our Research Articles

Page 602 of 1,424
    1. Neuroscience

    Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons

    Elise LV Malavasi, Aniket Ghosh ... Peter J Brophy
    Dynamic early clusters of nodal proteins in peripheral nerves represent a neurofascin-dependent developmental stage of node assembly during myelination that precedes heminode formation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

    Robert P Fuchs, Asako Isogawa ... Shingo Fujii
    DNA lesions formed by alkylating agents trigger double-strand breaks, in the absence of replication, by the action of MMR and BER at nearby O-alkyl and N-alkyl adducts, respectively.
    1. Chromosomes and Gene Expression

    DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

    Pedro Ortega, José Antonio Mérida-Cerro ... Andrés Aguilera
    Genetic and physical analyses reveal that DNA-RNA hybrids form fortuitously at DNA double-strand breaks during transcription and need removal to allow repair by homologous recombination.
    1. Cell Biology
    2. Developmental Biology

    Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

    Melissa T Adams, JaeAnn M Dwulet ... Barak Blum
    Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo-deficient islets of Langerhans in vivo.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The solubility product extends the buffering concept to heterotypic biomolecular condensates

    Aniruddha Chattaraj, Michael L Blinov, Leslie M Loew
    The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.
    1. Neuroscience

    Increased influence of prior choices on perceptual decisions in autism

    Helen Feigin, Shir Shalom-Sperber ... Adam Zaidel
    Perceptual decisions are influenced by preceding choices to a larger extent in individuals with autism spectrum disorder, such that they demonstrate a greater consistency bias.
    1. Developmental Biology
    2. Evolutionary Biology

    Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

    Luca Livraghi, Joseph J Hanly ... Chris D Jiggins
    The evolution of a butterfly mimetic phenotype is driven by modular cis-regulstory switches controlling a ‘hotspot’ gene.
    1. Stem Cells and Regenerative Medicine

    Distinct skeletal stem cell types orchestrate long bone skeletogenesis

    Thomas H Ambrosi, Rahul Sinha ... Charles KF Chan
    Functional and molecular analyses of two distinct skeletal stem cell populations establish the important role of stem cell diversity that provides a framework for novel investigations into skeletal biology.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue, Zhenlei Zhao ... Ying Zhang
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Microbiology and Infectious Disease

    Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

    Megan Culler Freeman, Alexandra I Wells ... Carolyn B Coyne
    Parallel studies in primary human airway cells and stem cell-derived enteroids show that Enterovirus D-68 differentially infects and induces innate immune signaling in the respiratory and intestinal epithelium.