Browse our Research Articles

Page 637 of 1,423
    1. Developmental Biology
    2. Neuroscience

    Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion

    Karina Chaudhari, Madhavi Gorla ... Greg J Bashaw
    Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
    1. Neuroscience

    Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans

    Michael Schaum, Edoardo Pinzuti ... Oliver Tüscher
    Response inhibition is initiated by the right inferior frontal gyrus (rIFG), and stopping performance is predicted by beta-band power as well as beta-band connectivity between rIFG and pre-supplementary motor area.
    1. Computational and Systems Biology

    Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

    Yuka Takemon, Joel M Chick ... Ron Korstanje
    mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.
    1. Microbiology and Infectious Disease

    Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

    Akshay Sabnis, Katheryn LH Hagart ... Andrew M Edwards
    Modulation of cytoplasmic lipopolysaccharide levels sensitises bacteria to polymyxin antibiotics, revealing a novel combination therapeutic approach.
    1. Ecology
    2. Microbiology and Infectious Disease

    Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

    Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
    The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
    1. Genetics and Genomics

    Whole-genome sequencing analysis of semi-supercentenarians

    Paolo Garagnani, Julien Marquis ... Claudio Franceschi
    Genetic variants located in DNA repair genes and a reduced burden of somatic mutations protect the oldest living persons from age-related diseases, allowing an healthy aging phenotype.
    1. Structural Biology and Molecular Biophysics

    The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

    Achinta Sannigrahi, Sourav Chowdhury ... Krishnananda Chattopadhyay
    How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?
    1. Cancer Biology
    2. Cell Biology

    Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

    Linda Julian, Gregory Naylor ... Michael F Olson
    In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, leading to sterile inflammation in the liver that increases tissue damage and suppresses tumor formation.
    1. Neuroscience

    An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

    Bo-yong Park, Richard AI Bethlehem ... Boris C Bernhardt
    Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.
    1. Cell Biology
    2. Medicine

    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

    Takeshi Ninchoji, Dominic T Love ... Lena Claesson-Welsh
    Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.