Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
Michael Schaum, Edoardo Pinzuti ... Oliver Tüscher
Response inhibition is initiated by the right inferior frontal gyrus (rIFG), and stopping performance is predicted by beta-band power as well as beta-band connectivity between rIFG and pre-supplementary motor area.
mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.
Rita de Cassia Pessotti, Bridget L Hansen ... Matthew F Traxler
The widespread occurrence of metabolically active streptomycetes in Odontotaenius disjunctus beetle frass may insulate their galleries against pathogenic fungal invasion through the production of diverse antimicrobial specialized metabolites.
Paolo Garagnani, Julien Marquis ... Claudio Franceschi
Genetic variants located in DNA repair genes and a reduced burden of somatic mutations protect the oldest living persons from age-related diseases, allowing an healthy aging phenotype.
How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?
In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, leading to sterile inflammation in the liver that increases tissue damage and suppresses tumor formation.
Bo-yong Park, Richard AI Bethlehem ... Boris C Bernhardt
Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.
Takeshi Ninchoji, Dominic T Love ... Lena Claesson-Welsh
Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.