Browse our Research Articles

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    1. Neuroscience

    Neural encoding of actual and imagined touch within human posterior parietal cortex

    Srinivas Chivukula, Carey Y Zhang ... Richard A Andersen
    Single neurons in human posterior parietal cortex encode actual and imagined touch within a shared neural substrate.
    1. Cancer Biology
    2. Neuroscience

    Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

    Zhi Zhang, Jae Whan Park ... Stephanie M Correa
    Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

    Xiangrong Chen, Yusuf I Ali ... Antony W Oliver
    Discovery and characterisation of a novel allosteric inhibitor-binding site in human Bloom syndrome protein.
    1. Chromosomes and Gene Expression

    Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

    Gang Wu, Yin Yeng Lee ... David F Smith
    RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of Stu2 recruitment to yeast kinetochores

    Jacob A Zahm, Michael G Stewart ... Matthew P Miller
    The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.
    1. Neuroscience

    The connectome of the adult Drosophila mushroom body provides insights into function

    Feng Li, Jack W Lindsey ... Gerald M Rubin
    Analysis of neuronal circuit architecture provides mechanistic insights into what an adult fly can learn, remember, and use to guide its behavior.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

    Haibin Yang, Leishu Lin ... Cong Yu
    Structural, biochemical, and cell biology study revealed that Rsu1, through binding to PINCH1, inhibits the actin bundling ability of ILK/PINCH/Parvin to regulate the actin dynamics at focal adhesion.
    1. Neuroscience

    Dissociation of task engagement and arousal effects in auditory cortex and midbrain

    Daniela Saderi, Zachary P Schwartz ... Stephen V David
    Data collected from two important auditory brain areas distinguish effects of generalized arousal and specific task engagement on neural sensory coding.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety, Tao Che ... Susruta Majumdar
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Genetics and Genomics

    Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

    Yang Lyu, Kristina J Weaver ... Scott D Pletcher
    Dietary choice per se is sufficient to modulate aging in Drosophila and through serotonergic control of peripheral metabolism.