Browse our Research Articles

Page 638 of 1,423
    1. Medicine
    2. Neuroscience

    Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials

    Maria M Cobo, Caroline Hartley ... Rebeccah Slater
    Measuring individual differences in noxious-evoked baseline sensitivity in neonates can substantially reduce sample sizes required in neonatal analgesic trials.
    1. Computational and Systems Biology

    Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health

    Michael S Lauer, Jamie Doyle ... Deepshikha Roychowdhury
    An analysis of peer review and funding outcomes of NIH research applications shows that funding disparities of topics preferred by African American Black investigators are not due to peer review preferences or biases.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson, Rachel A Johnston ... Jenny Tung
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

    Shiou-Ru Tzeng, Yin-Chu Tseng ... Chung-I Chang
    The N-terminal domains enable Lon protease to discriminate and capture selected protein species for degradation by exposed hydrophobic patches and flexible linkages to the hexameric core complex.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function

    Tessa M Bertozzi, Nozomi Takahashi ... Anne C Ferguson-Smith
    A retrotransposon-derived recombination event in inbred mice gives rise to an epiallele and tissue-specific phenotypes.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

    Christophe Caillat, Delphine Guilligay ... Winfried Weissenhorn
    The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.
    1. Medicine

    Sensitivity of ID NOW and RT–PCR for detection of SARS-CoV-2 in an ambulatory population

    Yuan-Po Tu, Jameel Iqbal, Timothy O'Leary
    Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.
    1. Microbiology and Infectious Disease

    Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities

    Lisa Mahler, Sarah P Niehs ... Miriam A Rosenbaum
    This microscale cultivation strategy will help in the discovery of novel bacterial species and their prioritization for antibiotic screening campaigns.
    1. Developmental Biology

    Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

    Swati Sharma, Richa Rikhy
    The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.
    1. Microbiology and Infectious Disease

    Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress

    David Ranava, Yiying Yang ... Raffaele Ieva
    The envelope stress factor DolP associates with the outer membrane protein assembly machinery and supports proper folding and functioning of BamA contributing to preserve envelope integrity.