Browse our Research Articles

Page 660 of 1,423
    1. Neuroscience

    Adaptation of spontaneous activity in the developing visual cortex

    Marina E Wosniack, Jan H Kirchner ... Julijana Gjorgjieva
    To generate stable and robust connectivity refinements, the amplitude of spontaneous activity events in the developing visual cortex adapts to the recent history of cortical activation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

    Rémi Allio, Marie-Ka Tilak ... Frédéric Delsuc
    High-quality genomes can be obtained from roadkill samples and used in population genomics for species delimitation with conservation implications.
    1. Developmental Biology
    2. Neuroscience

    NMDA receptors control development of somatosensory callosal axonal projections

    Jing Zhou, Yong Lin ... Samuel J Pleasure
    NMDAR receptors act in regulating axon guidance of somatosensory callosal projections in early postnatal life and the expression of EPHB2 receptors in target cells.
    1. Neuroscience

    Specialized contributions of mid-tier stages of dorsal and ventral pathways to stereoscopic processing in macaque

    Toshihide W Yoshioka, Takahiro Doi ... Ichiro Fujita
    Visual area MT signals binocular disparity quickly and robustly, whereas area V4 or its upstream area transforms the nature of the signals to derive a more sophisticated depth representation.
    1. Neuroscience

    Gap junction-mediated glycinergic inhibition ensures precise temporal patterning in vocal behavior

    Boris P Chagnaud, Jonathan T Perelmuter ... Andrew H Bass
    Inhibition provides a means for achieving temporal precision for rapid modulation of an acoustic signal in a vertebrate vocal network.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

    Manoj K Rathinaswamy, Zied Gaieb ... John E Burke
    The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.
    1. Cell Biology
    2. Neuroscience

    Latrophilin GPCR signaling mediates synapse formation

    Richard Sando, Thomas C Südhof
    Spatial restriction of GPCR signaling at nascent synapses by adhesion complexes drives excitatory synapse formation and specificity in the hippocampus.
    1. Genetics and Genomics

    Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

    Briana E Mittleman, Sebastian Pott ... Yoav Gilad
    A comparative analysis of human and chimpanzee polyadenylation site usage establishes alternative polyadenylation as another key mechanism underlying the genetic regulation of transcript and protein expression levels in primates.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

    Lorraine De Jesús-Kim, Larry J Friedman ... Stephen P Bell
    A multi-step process of helicase activation sensitizes replication initiation to the extent of replicative helicase phosphorylation.
    1. Cell Biology
    2. Neuroscience

    Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

    Lauren Tereshko, Ya Gao ... Piali Sengupta
    Neuropeptidergic signaling via cilia-localized receptors dynamically regulates excitatory synaptic drive in postnatal rat neocortical pyramidal neurons.