High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
Dominique Förster, Thomas O Helmbrecht ... Herwig Baier
The retinotectal map in zebrafish exhibits location-specific, functional specializations to match prey object movement in the visual field during the hunting sequence.
Jennifer EL Diaz, Mehmet Eren Ahsen ... Gustavo Stolovitzky
The transcriptomic profiles of the constituent monotherapies of synergistic drug pairs tend to be correlated and result in novel gene expression in the combinations.
New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.
Jennifer D Cohen, Alessandro P Sparacio ... Meera V Sundaram
Confocal imaging, electron microscopy, and genetic perturbations provide an unprecedented view of a complex and dynamic luminal matrix that determines tube shape during morphogenesis.
Connor Rogerson, Samuel Ogden ... Andrew D Sharrocks
Genome-wide redistribution of KLF5 binding leads to activation of a cell cycle gene expression programme and proliferation control in oesophageal cancer.
James P Herman, Fabrice Arcizet, Richard J Krauzlis
The pattern of spatial attention preferences in caudate neurons is altered by superior colliculus inactivation, demonstrating that a superior colliculus to basal ganglia link is important for selective attention.
The polo-like kinase (Plk1) phophorylates the C. elegans lamin LMN-1 to promote timely lamina disassembly, which is essential for the merging of the parental chromosomes at the beginning of life.
A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
