Timothy A Currier, Andrew MM Matheson, Katherine I Nagel
Electrophysiology identifies a population of fan-shaped body neurons that encode airflow in two directions relative to the fly midline and whose silencing disrupts proper orientation to airflow.
Time-resolved and site-directed in vivo photo-crosslinking analysis of VemP allows identification of both cis- and trans-elements required for its regulated arrest-cancelation.
Inhibitory neurons in the hypothalamus and amygdala push and pull on the midbrain vocal gating circuit to trigger and suppress ultrasonic vocalization (USV) production in the mouse.
Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
Laura Whitworth, Jacob Coxon ... Lalita Ramakrishnan
In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
José Antonio Escudero, Aleksandra Nivina ... Didier Mazel
The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
Nicolas Coudray, Georgia L Isom ... Damian C Ekiert
Structure of MlaFEDB ABC transporter with substrate bound in the outward-open pocket of MlaE provides mechanistic insights into lipid transport within the Gram-negative bacterial cell envelope.
Behnom Farboud, Catherine S Novak ... Barbara J Meyer
RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and determine nematode sex by controlling alternative non-productive pre-mRNA splicing of the master sex-determination switch gene.