Browse our Research Articles

Page 689 of 1,423
    1. Neuroscience

    Encoding and control of orientation to airflow by a set of Drosophila fan-shaped body neurons

    Timothy A Currier, Andrew MM Matheson, Katherine I Nagel
    Electrophysiology identifies a population of fan-shaped body neurons that encode airflow in two directions relative to the fly midline and whose silencing disrupts proper orientation to airflow.
    1. Biochemistry and Chemical Biology

    Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

    Ryoji Miyazaki, Yoshinori Akiyama, Hiroyuki Mori
    Time-resolved and site-directed in vivo photo-crosslinking analysis of VemP allows identification of both cis- and trans-elements required for its regulated arrest-cancelation.
    1. Neuroscience

    Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization

    Valerie Michael, Jack Goffinet ... Richard Mooney
    Inhibitory neurons in the hypothalamus and amygdala push and pull on the midbrain vocal gating circuit to trigger and suppress ultrasonic vocalization (USV) production in the mouse.
    1. Evolutionary Biology

    A Bayesian approach to dynamic homology of morphological characters and the ancestral phenotype of jawed vertebrates

    Benedict King, Martin Rücklin
    The ancestor of all known jawed vertebrates possessed a maxilla and premaxilla and was similar in morphology to the 'maxillate placoderms' from China.
    1. Genetics and Genomics
    2. Neuroscience

    A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

    François Kroll, Gareth T Powell ... Jason Rihel
    Zebrafish knockouts can be generated in a few hours directly from wild-type eggs and are suitable for studying continuous traits, including behaviour.
    1. Cancer Biology

    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

    Tessa M Popay, Jing Wang ... William P Tansey
    Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

    Laura Whitworth, Jacob Coxon ... Lalita Ramakrishnan
    In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
    1. Evolutionary Biology

    Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

    José Antonio Escudero, Aleksandra Nivina ... Didier Mazel
    The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
    1. Structural Biology and Molecular Biophysics

    Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

    Nicolas Coudray, Georgia L Isom ... Damian C Ekiert
    Structure of MlaFEDB ABC transporter with substrate bound in the outward-open pocket of MlaE provides mechanistic insights into lipid transport within the Gram-negative bacterial cell envelope.
    1. Chromosomes and Gene Expression

    Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

    Behnom Farboud, Catherine S Novak ... Barbara J Meyer
    RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and determine nematode sex by controlling alternative non-productive pre-mRNA splicing of the master sex-determination switch gene.