Browse our Research Articles

Page 723 of 1,393
    1. Neuroscience

    Altered functional connectivity during speech perception in congenital amusia

    Kyle Jasmin, Frederic Dick ... Adam Taylor Tierney
    Individuals with amusia, who have unreliable pitch processing, show decreased functional connectivity between right auditory and left language-related cortex during speech perception, demonstrating a neural basis for compensatory dimensional weighting.
    1. Cell Biology

    Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

    Vasyl Ivashov, Johannes Zimmer ... David Teis
    Metabolic cues enlist ubiquitin ligase adaptors for the selective control of cellular nutrient acquisition strategies.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of VASH1-SVBP bound to microtubules

    Faxiang Li, Yang Li ... Hongtao Yu
    Cryo-electron microscopy structure of vasohibin 1 bound to microtubules reveals how this enzyme prefers to remove the C-terminal tyrosine of α-tubulin in the microtubule lattice.
    1. Chromosomes and Gene Expression

    The nucleosome DNA entry-exit site is important for transcription termination and prevention of pervasive transcription

    A Elizabeth Hildreth, Mitchell A Ellison ... Karen M Arndt
    Disruption of the nucleosome DNA entry-exit site causes readthrough transcription of terminators, decreased nucleosome occupancy, and pervasive noncoding transcription, demonstrating this nucleosomal region protects the genome against inappropriate transcription.
    1. Neuroscience

    A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability

    Haggai Agmon, Yoram Burak
    A theory of coordinated neural network dynamics in multiple brain areas offers an explanation for several recent experimental findings in the hippocampus and medial entorhinal cortex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

    Xiaoshan Shi, Chunmei Chang ... James H Hurley
    Hydrogen-deuterium exchange, electron microscopy, and vesicle reconstitution show how binding of the autophagy adaptor NDP52 to the FIP200 subunit of the ULK1 complex triggers membrane binding in autophagy.
    1. Biochemistry and Chemical Biology

    A two-lane mechanism for selective biological ammonium transport

    Gordon Williamson, Giulia Tamburrino ... Arnaud Javelle
    A new cellular transport mechanism splits the substrate and separately translocates its fragments to achieve selectivity.
    1. Genetics and Genomics

    Population-scale proteome variation in human induced pluripotent stem cells

    Bogdan Andrei Mirauta, Daniel D Seaton ... Angus I Lamond
    Protein abundance changes across human-induced pluripotent stem cell lines reflect genetic variation across donors, with underlying mechanisms including modulation of RNA expression and modification of protein-coding sequences.
    1. Developmental Biology

    Polyploidy in the adult Drosophila brain

    Shyama Nandakumar, Olga Grushko, Laura A Buttitta
    Terminally differentiated neurons and glia can re-enter the cell cycle to become polyploid in the adult fly brain, to protect cells from DNA damage-associated death.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado, Abhilash Padavannil ... James A Letts
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.