GABA-A receptors on dopamine neuron axons not only depolarize the membrane but also limit action potential propagation, an effect potentiated by positive allosteric modulators of GABA-A receptors like diazepam (Valium).
KATANIN1 in stigma papilla cells prevents disordered pollen tube growth and straightens pollen tube direction, allowing the pollen tube to find its correct path to the underlying female tissues.
Melissa A Chiasson, Nathan J Rollins ... Douglas M Fowler
Human vitamin K epoxide reductase (VKOR) has a four transmembrane domain topology that supports the use of a homology model, enabling identification of active site residues and human variant impact.
Amphetamine reduces reward signaling by neurons in rat prefrontal cortex, but increases the stability of population dynamics, which account for animals’ increased task engagement, despite reduced reward motivation.
Margherita Perillo, Nathalie Oulhen ... Gary Wessel
Multimodal technologies and the experimental tractability of sea urchin embryos reveal diverse regulatory mechanisms and unique genes for distinct pigment cell states.
Jesus Javier Ballesteros, Jessica Blair Briscoe, Yumiko Ishizawa
Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.
Catherine G Triandafillou, Christopher D Katanski ... D Allan Drummond
When translation stops, cells require intracellular acidification to turn on the conserved heat shock response during stress, and stress-triggered acidification (common in eukaryotes) is adaptive, promoting cell and population fitness.
Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
