Browse our Research Articles

Page 751 of 1,395
    1. Cell Biology
    2. Genetics and Genomics

    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

    Tao Huang, Shenli Yuan ... Hongbin Liu
    ZCWPW1 is a histone modification reader that localizes to DMC1-labelled double-strand break hotspots in a largely PRDM9-dependent manner, where it facilitates completion of synapsis by mediating DSB repair process.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet, Alexandra Vandervelde ... Lendert Gelens
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Genetics and Genomics

    Germline burden of rare damaging variants negatively affects human healthspan and lifespan

    Anastasia V Shindyapina, Aleksandr A Zenin ... Vadim N Gladyshev
    Rare highly damaging mutations that are present in most human genomes decrease lifespan and are associated with an earlier onset of chronic diseases.
    1. Neuroscience

    Feedback contribution to surface motion perception in the human early visual cortex

    Ingo Marquardt, Peter De Weerd ... Kâmil Uludağ
    Novel evidence for a role of feedback in the perception of uniform surfaces in the human brain suggests that feedback already re-enters at an early visual processing stage.
    1. Epidemiology and Global Health
    2. Medicine

    Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

    Lucy Rivett, Sushmita Sridhar ... Michael P Weekes
    3% of >1,000 asymptomatic healthcare workers in their workplace tested positive for SARS-CoV-2, suggesting that comprehensive screening programmes are vital to prevent acquisition of COVID-19 in hospitals.
    1. Neuroscience

    SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

    Yoichi Araki, Ingie Hong ... Richard L Huganir
    Detailed SYNGAP1 splice variant characterization uncovers distinct isoform functions and biochemical properties contributing to critical aspects of neurodevelopment, providing previously unknown isoform-level insight into SYNGAP1-related cognitive disorders.
    1. Developmental Biology
    2. Neuroscience

    Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence

    Michael A Hahn, Dominik Heib ... Randolph F Helfrich
    An individualized cross-frequency coupling approach identified slow oscillation-spindle coupling strength as a novel mechanism that mediates memory formation during cortical maturation.
    1. Evolutionary Biology
    2. Neuroscience

    Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

    Luis Alfonso Yañez-Guerra, Xingxing Zhong ... Maurice R Elphick
    Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.
    1. Computational and Systems Biology
    2. Neuroscience

    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

    Amin Haghani, Mafalda Cacciottolo ... Caleb E Finch
    Transcriptome analysis of mouse brain revealed that the APOE4 allele and sex can alter air pollution neurotoxicity in adults.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.