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Before returning home, and when using novel routes, dogs align along the north-south axis, presumably to bring the mental map into register with the magnetic compass.

TMEM95, a protein localized to the sperm acrosome cap, is essential for fertilization.

Cell protease and cell fate decisions are regulated by a bone fide force-sensor, the Piezo1 channel, and by this means achieve integration with the mechanical environment.

Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.

Primate-specific miR-934 mediates neurogenesis and downstream neuronal differentiation processes, modulating the expression of genes associated with the subplate, a region most prominent in primates, emerging during early cortical development.

Adaptations in protein synthesis and mRNA surveillance machinery enabled the malaria-causing parasite P. falciparum to efficiently and accurately translate long polyA nucleotide runs into long poly-lysine peptides.

A key target of the HIV-1 Vpr accessory protein is identified, whose depletion causes increased HIV-1gene expression and cell cycle arrest.

Wnt/beta-catenin signaling is essential for the specification of dorsal cell fate in amphioxus, suggesting a common evolutionary origin for the formation of the dorsal organizer in chordates.

Structural and biochemical analysis of an abundant and conserved protein complex called EMC shows how it is likely to insert nascent membrane proteins into the endoplasmic reticulum membrane.

Cell biological and genetic analyses reveal how budding yeast cells optimize Spindle Assembly checkpoint signaling to maximize chromosome segregation accuracy and minimize unnecessary delays in anaphase onset.