Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.
Alexandra Schauer, Diana Pinheiro ... Carl-Philipp Heisenberg
Blastoderm tissue organization and patterning in zebrafish explants is driven by a genetically encoded and controlled self-assembly mechanism, rather than a bonafide self-organization mechanism.
Perceived imminence of threat and resulting intensity of defensive responses during serial compound stimulus conditioning are determined by auditory stimulus salience, not cue sequence as recently reported.
John ME Nichols, Vlatka Antolović ... Jonathan R Chubb
Efficient dedifferentiation is characterized by robustness to mutation, flexibility in ordering of cellular events and reversal of developmental changes along a single gene expression trajectory.
A linear array of spectrin tetramers imparts mechanical stability to axons by allowing spectrin domains to unfold reversibly when an axon is stretched, thereby acting as tension buffers.
Isabella V Soluri, Lauren M Zumerling ... Shelby A Blythe
Mechanisms for shaping the chromatin accessibility landscape operate during development to regulate how embryonic patterning information is interpreted at the level of gene regulatory networks.