Giardia, a multi-ciliated parasitic protist, maintains four different flagellar lengths by balancing flagellar length-independent IFT-mediated assembly with length-dependent kinesin-13 mediated disassembly.
Direct-to-consumer genetic genealogy services that allow users to upload their own datasets are vulnerable to attacks on genetic privacy that exploit the structure of genetic variation.
A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
Cascades of transient pairwise interactions, stabilized by multisensory inputs, drive the formation of a well-organized social structure from a group of loosely distributed flies.
The conductance-based encoding model creates a new bridge between statistical models and biophysical models of neurons, and infers visually-evoked excitatory and inhibitory synaptic conductances from spike trains in macaque retina.
Olivier Thouvenin, Ludovic Keiser ... Claire Wyart
The combination of data and modelling shows the mechanisms underlying bidirectional flow of cerebrospinal fluid and its impact on long range transport in the CSF between brain and spinal cord.
Tina B Lonsdorf, Maren Klingelhöfer-Jens ... Christian J Merz
Exclusion of participants in tasks with a learning element can introduce substantial bias and needs to be carefully considered and transparently reported and justified.
Sophia Karpenko, Sebastien Wolf ... Georges Debrégeas
Light-seeking strategies in Zebrafish larvae are dissected using a virtual-reality assay, and these data are used to establish minimal stochastic and neural-circuits models that quantitatively capture this behavior.
Douaa Mugahid, Marian Kalocsay ... Marc W Kirschner
Besides a cell autonomous role in regulating proliferation, YAP regulates the production of several extracellular molecules allowing for population-level coordination of cell growth and death.
