Browse our Research Articles

Page 799 of 1,380
    1. Neuroscience

    Navigating the garden of forking paths for data exclusions in fear conditioning research

    Tina B Lonsdorf, Maren Klingelhöfer-Jens ... Christian J Merz
    Exclusion of participants in tasks with a learning element can introduce substantial bias and needs to be carefully considered and transparently reported and justified.
    1. Computational and Systems Biology
    2. Neuroscience

    From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

    Sophia Karpenko, Sebastien Wolf ... Georges Debrégeas
    Light-seeking strategies in Zebrafish larvae are dissected using a virtual-reality assay, and these data are used to establish minimal stochastic and neural-circuits models that quantitatively capture this behavior.
    1. Cell Biology

    YAP regulates cell size and growth dynamics via non-cell autonomous mediators

    Douaa Mugahid, Marian Kalocsay ... Marc W Kirschner
    Besides a cell autonomous role in regulating proliferation, YAP regulates the production of several extracellular molecules allowing for population-level coordination of cell growth and death.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

    Rosa Maria Porreca, Emilia Herrera-Moyano ... Jean-Baptiste Vannier
    TRF1 suppresses replication fork stalling, which triggers break induced replication at telomeres associated with DNA damage response, alteration in the telomere chromatin environment, and re-localisation of telomeres to PML bodies.
    1. Developmental Biology
    2. Immunology and Inflammation

    Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

    Ken-ichi Hirano, Akiko Suganami ... Katsuto Hozumi
    Notch ligand, Dll4 needs the flexible loop structure in the MNNL domain of the extracellular region to efficiently trigger the Notch signaling.
    1. Structural Biology and Molecular Biophysics

    The structure of the endogenous ESX-3 secretion system

    Nicole Poweleit, Nadine Czudnochowski ... Oren S Rosenberg
    The structure of the endogenous ESX-3 secretion system reveals a highly coordinated inner membrane complex and suggests a mechanism for the regulated secretion of ESX substrates.
    1. Developmental Biology

    Compartmentalized oskar degradation in the germ plasm safeguards germline development

    Catherine E Eichler, Anna C Hakes ... Elizabeth R Gavis
    RNP granules confer temporal and spatial regulation of oskar mRNA degradation to minimize inheritance of oskar mRNAby germ cells and thereby protect germline development.
    1. Developmental Biology
    2. Genetics and Genomics

    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

    Rachel K Lex, Zhicheng Ji ... Steven A Vokes
    GLI3 represses Hedgehog target gene expression by regulating histone modifications at a subset of tissue-specific GLI-bound enhancers.
    1. Neuroscience

    Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb

    Justin Losacco, Daniel Ramirez-Gordillo ... Diego Restrepo
    Tetrode recordings show that the amplitude of gamma oscillations encodes for information on contextual odorant identity when observed at the peak phase of the theta oscillation in the olfactory bulb.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji

    Alasdair D Henderson, Maite Aubry ... Adam J Kucharski
    A combination of eight serological surveys shows a decline in seroprevalence over a two-year period following the first reports of Zika transmission in Fiji and French Polynesia.