Browse our Research Articles

Page 800 of 1,380
    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim, Christian Berrios ... William C Hahn
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Neuroscience

    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

    Liang Zhou, Chong-Yu Shao ... Ying Shen
    Gab1 is a key downstream effector of PDGF signaling and essential to oligodendrocyte differentiation by linking PDGF signaling with GSK3β/β-catenin module.
    1. Neuroscience

    Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex

    Viktor Szegedi, Melinda Paizs ... Karri Lamsa
    Abundant self-inhibitory synapses in the layer 2/3 of human neocortex strongly regulate the function of basket cells.
    1. Neuroscience

    Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition

    E Mae Guthman, Joshua D Garcia ... Molly M Huntsman
    Sst+ interneurons drive feedforward inhibition in the basolateral amygdala, and thus provide a framework for why interneuron subtypes may mediate different archetypal circuit motifs across different brain regions.
    1. Cell Biology
    2. Neuroscience

    Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

    Ori J Lieberman, Micah D Frier ... David Sulzer
    In addition to its classic role in synaptic function and plasticity, macroautophagy regulates neuronal intrinsic excitability via degradation of acetylated Kir2 channels to control neurotransmission.
    1. Neuroscience

    Resolving multisensory and attentional influences across cortical depth in sensory cortices

    Remi Gau, Pierre-Louis Bazin ... Uta Noppeney
    The different laminar profiles observed across the cortical depth for multisensory and attentional influences indicate partly distinct neural circuitries of information-flow control.
    1. Neuroscience

    LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses

    Alessandra Sclip, Thomas C Südhof
    LAR-RPTPs are not essential for synapse formation, but they are important determinants of synapse properties as they contribute to regulate postsynaptic NMDA receptor function.
    1. Microbiology and Infectious Disease

    Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

    Genevieve S Dobihal, Yannick R Brunet ... David Z Rudner
    Molecular genetic analyses define the first homeostatic control pathway that maintains cell wall remodeling activity during bacterial growth.
    1. Developmental Biology

    Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

    Xue Hao, Shimin Wang ... Lei Zhang
    The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.
    1. Medicine

    Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

    Hua-Qian Yang, Marta Pérez-Hernández ... William A Coetzee
    The functional interaction of Na+ and KATP channels at the intercalated disk of cardiomyocytes depends on Ankyrin G and is clinically relevant since KATP channel mutations affect Na+ channel expression.