Browse our Research Articles

Page 869 of 1,510
    1. Neuroscience

    The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information

    Takahiro Doi, Yunshu Fan ... Long Ding
    Caudate neurons encode reward and sensory information and the effects of caudate microstimulation mimic the monkeys' voluntary reward bias strategy.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra, Mohammad Zeeshan ... Mathieu Brochet
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia

    Santosh Kumar Kuncha, Vinitha Lakshmi Venkadasamy ... Rajan Sankaranarayanan
    Identification of a two-tier functional redundancy to combat proteostasis imbalance induced due to tRNA expansion and oxidative stress in multicellular animals.
    1. Cell Biology
    2. Developmental Biology

    Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation

    Pieter R Norden, Amélie Sabine ... Tsutomu Kume
    Genetic and molecular analyses show that FOXC1 and FOXC2 play a role in controlling lymphatic valve maintenance as key mediators of mechanotransduction to control cytoskeletal organization and RhoA/ROCK signaling.
    1. Cancer Biology

    The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

    Zane A Gibbs, Luis C Reza ... Angelique W Whitehurst
    Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.
    1. Ecology

    Positive density dependence acting on mortality can help maintain species-rich communities

    Thomas G Aubier
    Some forms of positive density-dependence can favor species coexistence even if competitive species benefit the most from positive density-dependence.
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim, Lea Adolf ... Simon Heilbronner
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Neuroscience

    AMPAR/TARP stoichiometry differentially modulates channel properties

    Federico Miguez-Cabello, Nuria Sánchez-Fernández ... David Soto
    A variable number of auxiliary subunit molecules (TARPs) accompanying AMPARs have a differential impact on channel behavior showing also striking differences between AMPAR subtypes.
    1. Neuroscience

    Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells

    Ramesh Chittajallu, Kurt Auville ... Chris J McBain
    Similar to their mouse counterparts, human neurogliaform cells that comprise a specialized from of inhibitory neuron, possess the ability to modulate their intrinsic excitability in response to ongoing network activity.