Huan Song, Henrik Larsson ... Unnur A Valdimarsdóttir
A population-based analysis demonstrates that surviving twins who lose their co-twins by death are at considerably elevated risks of developing psychiatric disorders.
Amyloid beta, the major component of plaques in Alzheimer's disease, acutely and reversibly signals to modulate sleep as a function of oligomeric length, independently of neuronal loss.
Kevin A Bolding, Shivathmihai Nagappan ... Kevin M Franks
Intracortical circuits in mouse olfactory cortex stabilize odor-evoked activity patterns when upstream inputs, from olfactory bulb, become degraded under anesthesia.
CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).
TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
Racquel Domingo-Gonzalez, Fabio Zanini ... Cristina M Alvira
Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.
Sabrina Bianca Bennstein, Sandra Weinhold ... Markus Uhrberg
Neonatal ILC1-like cells are functionally immature but have the unique potential to generate NK cells characterized by downregulation of NKG2A and a highly diverse KIR receptor repertoire.
Linda Grigoraki, Xavier Grau-Bové ... Hilary Ranson
Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.
Expression of a psoriasis-associated CARD14E138A mutant in keratinocytes induces TNF-dependent localised skin and systemic inflammation independently of the adaptive immune system.