Browse our Research Articles

Page 871 of 1,521
    1. Developmental Biology

    Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila

    Satish Kumar Tiwari, Ashish Ganeshlalji Toshniwal ... Lolitika Mandal
    Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..
    1. Neuroscience

    A size principle for recruitment of Drosophila leg motor neurons

    Anthony W Azevedo, Evyn S Dickinson ... John C Tuthill
    Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.
    1. Neuroscience

    Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

    Nathan Cermak, Stephanie K Yu ... Steven W Flavell
    Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

    Lukas S Stelzl, Despoina AI Mavridou ... Christina Redfield
    The cysteine pair oxidation state in nDsbD acts as a ‘switch’ controlling the presence or absence of frustration in the active-site and determining the dynamic behavior of the cap loop.
    1. Neuroscience

    Different dendritic domains of the GnRH neuron underlie the pulse and surge modes of GnRH secretion in female mice

    Li Wang, Wenya Guo ... Yanping Kuang
    Electrical activity at the gonadotropin-releasing hormone (GnRH) neuron cell body and proximal dendrites is not required for the pulsatile secretion of GnRH that controls fertility.
    1. Neuroscience

    Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm

    Heidi IL Jacobs, Nikos Priovoulos ... Kâmil Uludağ
    By combining ultra-high-field imaging with physiological and saliva measures it is established that interactions between locus coeruleus, hippocampus and amygdala vary along emotional memory stages, putatively reflecting distinct cognitive states.
    1. Neuroscience

    Different methods of fear reduction are supported by distinct cortical substrates

    Belinda PP Lay, Audrey A Pitaru ... Mihaela D Iordanova
    Extinction and overexpectation lead to the same behavioural outcome, that is, reduction in learned fear, but engage different cortical areas.
    1. Neuroscience

    Control of adaptive action selection by secondary motor cortex during flexible visual categorization

    Tian-Yi Wang, Jing Liu, Haishan Yao
    The secondary motor cortex causally contributes to flexible action selection during stimulus categorization with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus–action association.
    1. Chromosomes and Gene Expression

    Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

    Suna Gulay, Neha Gupta ... Alan G Hinnebusch
    Interactions of eIF4A and eIF4E with specific amino-acids in the N-terminal domain of DEAD-box helicase Ded1 enhance bulk polysome assembly and translation of reporter mRNAs with structured leaders in vivo.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.