Browse our Research Articles

Page 871 of 1,400
    1. Cell Biology

    Evidence that a positive feedback loop drives centrosome maturation in fly embryos

    Ines Alvarez-Rodrigo, Thomas L Steinacker ... Jordan W Raff
    Polo kinase recruitment by the protein Spd-2 to the pericentriolar scaffold is a key element of the positive feedback loop which drives the expansion of the mitotic centrosomes in flies.
    1. Neuroscience

    The nature of the animacy organization in human ventral temporal cortex

    Sushrut Thorat, Daria Proklova, Marius V Peelen
    The animacy organization in human ventral visual cortex is driven by both the presence of animal-diagnostic visual features and the psychological property of agency.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

    Jinsheng Zhu, Kelvin Lau ... Michael Hothorn
    Genetic and biochemical analysis of two enzymes reveals that inositol pyrophosphate signaling molecules allow plants to sense and regulate cellular phosphate levels, and to take up more phosphate when needed.
    1. Neuroscience

    Statistical learning attenuates visual activity only for attended stimuli

    David Richter, Floris P de Lange
    Prior expectations, induced by statistical learning, affect sensory processing only for attended stimuli, thereby constraining neurocomputational theories that cast perception as an inferential process integrating prior knowledge and sensory evidence.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

    Takeshi Katsuda, Juntaro Matsuzaki ... Takahiro Ochiya
    Human chemically induced liver progenitors (hCLiPs), which are generated from primary human hepatocytes, exhibit the potential to repopulate injured livers of host mice with efficiency > 90%.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

    Sidney M Bell, Leah Katzelnick, Trevor Bedford
    Each dengue serotype contains moderate antigenic diversity, and population immunity drives clade turnover in a hyperendemic population.
    1. Neuroscience

    Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

    Irene Bolea, Alejandro Gella ... Albert Quintana
    Glutamatergic brainstem neurons drive motor and respiratory deficits, and GABAergic basal ganglia neurons cause hypothermia and fatal epileptic events, in a model of mitochondrial disease.
    1. Neuroscience

    An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway

    Sho Aoki, Jared B Smith ... Xin Jin
    A novel connection from ventral striatum to motor cortex enables emotion and motivation to influence action and motor control.
    1. Cell Biology

    Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

    Andrew Ying Hui Ng, Ziqing Li ... Shuying Yang
    Rgs12 protein is a novel regulator of the Nrf2 protein by facilitating the proteasomal degradation of the transcription factor during osteoclast differentiation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Regulation of Eag1 gating by its intracellular domains

    Jonathan R Whicher, Roderick MacKinnon
    Interactions between the voltage sensor and intracellular domains modulate voltage-dependent gating and calmodulin inhibition in the voltage-gated potassium channel Eag1.