Nalin Leelatian, Justine Sinnaeve ... Jonathan M Irish
A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
Elizabeth B Draganova, Jiayan Zhang ... Ekaterina E Heldwein
Interactions were visualized between the nuclear egress complex from herpes simplex virus and a capsid protein that could promote nucleocytoplasmic translocation of the capsid in infected cells.
Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.
The loss of lamination in mammalian brain structures under cellular heterotopia carries with it non-uniform ramifications for the various components of the canonical CA1 microcircuitry.
Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
Abril Angélica Escamilla-Ayala, Ragna Sannerud ... Wim Annaert
Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
Human NK cells engineered to express a PD-L1 chimeric antigen receptor can control murine and human tumors and reduce myeloid cells expressing high levels of PD-L1.
Prevention and antivenom treatment could reduce snakebite deaths, which killed 1.2 million Indians from 2000-2019, about 70% of which occurred in eight states, and half during four rainy months.
In yeast, a fluorescent vacuolar cargo departs from Golgi cisternae early in the TGN stage of maturation, and traffic from prevacuolar endosomes to the vacuole apparently involves a kiss-and-run mechanism.
