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Deep brain stimulation can selectively modify neural activity within the subthalamic nucleus to modify decisions under uncertainty in human subjects.

Piezo1 exhibits markedly different kinetic behavior in different cellular contexts.

Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.

A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.

Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.

Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.

The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.

The dorsolateral prefrontal cortex integrates concurrent externally and internally generated predictions of task demand to guide information processing, while the medial prefrontal cortex corrects its prediction error based on actual task demand.

Cytological and biochemical analyses reveal Arabidopsis formin 2 is involved in regulating PD permeability by anchoring actin filaments to PD and stabilizing them through actin filament barbed end capping activity.

Rather than acting as passive and neutral co-factors for proneural proteins, E proteins play an active role in modulating the way the distinct proneural proteins instruct neurogenesis.