Browse our Research Articles

Page 981 of 1,398
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Developmental Biology
    2. Immunology and Inflammation

    Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus

    Federico Andrea Moretti, Sarah Klapproth ... Markus Moser
    T cell progenitor homing into the thymus requires kindlin-3 to stabilize their adhesion to vascular integrin ligands when blood flow velocities and shear rates increase during development.
    1. Neuroscience

    Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9

    Barbara Commisso, Lingjun Ding ... Francesco Roselli
    The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
    1. Neuroscience

    Constraints on neural redundancy

    Jay A Hennig, Matthew D Golub ... Steven M Chase
    The distribution of redundant neural activity is coupled with task-relevant activity, which may limit the extent to which redundancy can be exploited by the brain for computation.
    1. Neuroscience

    Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

    Wenxuan He, David Kemp, Tianying Ren
    Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl, Zeynep Hein ... Sebastian Springer
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel, Masashi Goto ... Diane M Simeone
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Cell Biology

    The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

    Rengasayee Veeraraghavan, Gregory S Hoeker ... Robert G Gourdie
    Structural and functional investigations identify a structural unit for ephaptic coupling in the heart, and provide the mechanistic basis for a novel strategy for the treatment of arrhythmias.
    1. Neuroscience

    Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

    Romain Durand-de Cuttoli, Sarah Mondoloni ... Alexandre Mourot
    In vivo deconstruction of reward-related behaviors with circuit and pharmacological specificity using designer, light-controllable nicotinic acetylcholine receptors.
    1. Neuroscience

    A neural-level model of spatial memory and imagery

    Andrej Bicanski, Neil Burgess
    The BB model explains spatial cognition in terms of interactions between specific neuronal populations, providing a common computational framework for the human neuropsychological and in vivo animal electrophysiological literatures.