Browse our Research Articles

Page 982 of 1,400
    1. Ecology
    2. Evolutionary Biology

    Convergence between the microcosms of Southeast Asian and North American pitcher plants

    Leonora S Bittleston, Charles J Wolock ... Anne Pringle
    Host characteristics drive the assembly of similar communities within the convergently evolved and geographically distant pitcher ecosystems of carnivorous pitcher plants.
    1. Microbiology and Infectious Disease

    NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin

    Ucheor B Choi, Minglei Zhao ... Axel T Brunger
    NSF is part of a membrane trafficking quality control system that disassembles both properly formed and off-pathway SNARE complexes, and the disassembly activity may be regulated by complexin.
    1. Neuroscience

    Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

    Jessica E Messier, Hongmei Chen ... Mingshan Xue
    A high axonal chloride concentration explains why activation of light-gated chloride channels causes neurotransmitter release, and a novel hybrid somatodendritic targeting motif ameliorates this phenomenon and improves their inhibitory function.
    1. Neuroscience

    Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

    Shaun R Patel, Todd M Herrington ... Emad N Eskandar
    Deep brain stimulation can selectively modify neural activity within the subthalamic nucleus to modify decisions under uncertainty in human subjects.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

    Josefina Inés del Mármol, Kouki K Touhara ... Roderick MacKinnon
    Piezo1 exhibits markedly different kinetic behavior in different cellular contexts.
    1. Cell Biology

    Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

    Marco Novais-Cruz, Maria Alba Abad ... Cristina Ferrás
    Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen, Lei Li ... Lin Mei
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Plant Biology

    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

    Amr Nassrallah, Martin Rougée ... Fredy Barneche
    Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
    1. Cancer Biology

    tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

    Myron S Ignatius, Madeline N Hayes ... David M Langenau
    Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway

    Zheng Wang, Catherine Wu ... Tony Hunter
    The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.