Structural and functional analysis of the OTOP3 channel from Xenopus tropicalis offers insights into the mechanism of ion transport and regulation in the otopetrin proton channel family.
NOD-like receptor NLRP12 is a critical regulator of hepatocyte proliferation and its activation could be therapeutically used to suppress hepatocellular carcinoma.
Shahrzad Kharabian Masouleh, Simon B Eickhoff ... Alzheimer's Disease Neuroimaging Initiative
Empirical evaluations demonstrate the low probability of finding and replicating significant associations between psychological tests and brain structure in healthy adults, highlighting the importance out-of-sample replication of exploratory findings.
Wanqing Shao, Sergio G-M Alcantara, Julia Zeitlinger
Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
Fabienne Benz, Viraya Wichitnaowarat ... Stefan Liebner
Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
Luis Carrillo-Reid, Michelle Day ... D James Surmeier
In mouse models of Huntington's disease, striatal spiny projection neurons up-regulate dendritic potassium channels, which impairs their normal function, but a zinc finger gene therapy can reverse this deficit.
Both exogenous and endogenous genes can be highly activated in cells by a new dCas9-based activator, CRISPR-assisted trans enhancer, that can be used to activate genes for biomedical applications.
Ruben M Atilho, Gayan Mirihana Arachchilage ... Ronald R Breaker
Many bacteria use a tiny riboswitch aptamer to sense the thiamin precursor HMP-PP to regulate the production of another thiamin precursor HET-P to efficiently biosynthesize this essential coenzyme.
