Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.
Diego Candia-Rivera, Federico Raimondo ... Jacobo D Sitt
Brain-heart interactions under the processing of auditory irregularities could help to distinguish whether a patient is in a vegetative state or in a minimally conscious state.
Deep reinforcement model and experimental evaluations identified a small-molecule CRM1 inhibitor that can selectively ablate extranodal NK/T cell lymphoma cells.
Protein kinase dysregulation, implicated in various diseases via cell signaling pathways, can be therapeutically and experimentally managed through allosteric modulation, facilitated by a dynamic network of interactions, with computational techniques enabling precise control in live systems.
A toxin-antidote element, identified for its role as a selfish genetic element that spreads through a population by killing certain offspring, also plays a beneficial role to the host.
Louiza S Velentzis, Megan A Smith ... Karen Canfell
Results from this modelled analysis indicate that short-term delays in HPV vaccination of adolescents are unlikely to have substantial long-term effects on HPV-related cancers, provided catch-up of missed vaccine doses can be implemented.
Operating as a serum profiling tool for dengue infection and vaccination, the D2-FLM variant, which is insensitive to antibody-dependent enhancement-prone fusion loop antibodies, also offers potential for a safer dengue virus vaccine.
A computer-assisted revision of a unique fossil from Kenya supports the hypothesis that the modern features of our brain emerged recently in the human evolutionary history.
Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
