Browse our Short Reports

Page 9 of 63
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

    Maire Gavagan, Noel Jameson, Jesse G Zalatan
    A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.
    1. Epidemiology and Global Health

    A review of HPV and HBV vaccine hesitancy, intention, and uptake in the era of social media and COVID-19

    Emily K Vraga, Sonya S Brady ... Shalini Kulasingam
    A review of the current empirical literature underscores the need for longitudinal research examining potential spillover effects between hesitancy, intention, or uptake for the COVID vaccine and HPV and HBV vaccines, especially to account for social media misinformation.
    1. Developmental Biology
    2. Plant Biology

    ECS1 and ECS2 suppress polyspermy and the formation of haploid plants by promoting double fertilization

    Yanbo Mao, Thomas Nakel ... Rita Groß-Hardt
    The endopeptidases ECS1 and ECS2 regulate double fertilization and their modulation is a powerful tool for the induction of haploids and the formation of triparental plants, which are two agronomically relevant breeding targets.
    1. Cancer Biology

    Precision RNAi using synthetic shRNAmir target sites

    Thomas Hoffmann, Alexandra Hörmann ... Ralph A Neumüller
    Artificial RNA interference is a novel loss-of-function method for highly stringent target validation in oncology and beyond.
    Version of Record
    Short Report
    • Valuable
    • Compelling
    1. Ecology
    2. Evolutionary Biology

    Megafaunal extinctions, not climate change, may explain Holocene genetic diversity declines in Numenius shorebirds

    Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt
    Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
    1. Microbiology and Infectious Disease

    A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection

    Jessie Kulsuptrakul, Elizabeth A Turcotte ... Patrick S Mitchell
    HIV-1 infection activates the human CARD8 inflammasome via innate immune recognition of HIV-1 viral protease activity.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids

    Galina Popova, Hanna Retallack ... Tomasz Nowakowski
    Combination of primary brain culture and single-cell RNA sequencing in brain organoids identifies microglia as the main target of rubella virus infection.
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    Short Report
    • Important
    • Compelling
    1. Developmental Biology
    2. Genetics and Genomics

    Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest

    Lingli Huang, Wenqing Li ... Jianqiang Bao
    Biallelic MAD2L1BP variants contribute to oocyte metaphase I arrest in women with primary infertility and p31comet is required for human oocyte maturation.
    1. Microbiology and Infectious Disease

    Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations

    Daan F van den Berg, Baltus A van der Steen ... Stan JJ Brouns
    A new perspective on the 50-year old mystery of why phages encode their own tRNAs.
    1. Ecology
    2. Evolutionary Biology

    Metabolic consequences of various fruit-based diets in a generalist insect species

    Laure Olazcuaga, Raymonde Baltenweck ... Julien Foucaud
    Metabolomic analyses indicate that diet generalism may stem from a neutral metabolic response to different chemistries, rather than from an accumulation of specific adaptations.