A novel technology for recording muscle activity provides unprecedented access to the electrical signals that control the body across muscles, species, and behaviors.
Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
Ernesto Ciabatti, Ana González-Rueda ... Marco Tripodi
SiR does not revert to wild type when produced in high-TEVp cell lines, is non-toxic in vivo, maintains transsynaptic spreading capabilities and revertant mutations do not accumulate during in vivo experiments.
Yong-Il Kim, Rebecca O'Rourke, Charles G Sagerström
Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.
Functional ultrasound imaging was used to monitor brain hemodynamics and sensory-evoked thalamocortical functions in awake rats pre- and post-stroke, advancing our understanding toward new therapeutic developments.
Low-profile tetrodes that are compatible with wide-field imaging provide the opportunity to evaluate the relationship between spiking neurons and broad networks.
Hannah Jones, Jenny A Willis ... Giorgio F Gilestro
Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.
