An ellipse of insignificant analysis is a robust method for ascertaining the strength of even large dichotomous outcome trials in biomedical science, and is a novel means to detect potentially dubious results and research fraud.
Dirk H Siepe, Lukas T Henneberg ... K Christopher Garcia
A proteo-genomic CRISPR activation screening workflow to accelerate the identification of novel interactions between the secreted and membrane proteome with the potential to define new biological processes and identify future therapeutic targets.
Dakota E McCoy, Benjamin Goulet-Scott ... John Kartesz
Across 63 large US cities, street tree communities are shaped by climate, clustered by species, and made more similar between cities due to the presence of introduced species.
An improved culture method for explanted adult Drosophila organs allows the live-imaging of damage response, cell differentiation, and tracing of progenitor cell lineages through multiple rounds of division.
Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado ... Ralf H Adams
Reactive endothelial venules are a new vessel subtype characterized by consistent expression of cell adhesion molecules, preferential leukocyte transmigration, association with perivascular macrophages, and the initiation of CNS immune responses.
Under fluid shear, living cells deform elliptically, align in flow direction, and rotate, from which their frequency-dependent viscoelastic properties can be inferred.
Andrea Navas-Olive, Rodrigo Amaducci ... Liset M de la Prida
A new method is described to identify sharp-wave ripples from the rodent hippocampus with deep learning techniques, which may help to identify and characterize previously undetected physiological events.
With three simple steps in 48 hr, EZ Clear effectively renders adult mouse organs optically transparent while simultaneously preserving signal from synthetic and endogenous fluorescent reporters and is compatible with wholemount immunostaining and cryosectioning followed by histological or immunofluorescent staining.
