Simultaneous calcium imaging and cell-attached recording in GCaMP6 transgenic mice in vivo reveals spiking-fluorescence relationship that supports more refined inference of neuronal activities from calcium imaging data.
Ibrahim T Mughrabi, Jordan Hickman ... Stavros Zanos
Long-term, dose-controlled vagus nerve stimulation (VNS) is feasible in mice using a multi-lab validated implantation procedure, allowing therapeutic testing of VNS in many disease models.
The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.
Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.
'Cellular Electron Microscopy 500,000 images' (CEM500K) is a highly heterogeneous, information-rich, non-redundant, unlabeled EM dataset curated to pre-train DL algorithms for better model generalization on EM segmentation tasks.
tTARGIT AAVs offer a new approach to manipulate intersectional populations that produce selective and robust transgene expression and are easily modified.
Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.
Friederike E Kohrs, Ilsa-Maria Daumann ... P Robin Hiesinger
The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.
