Browse the latest research

Page 116 of 1,780
    1. Stem Cells and Regenerative Medicine

    Chromatin activity of IκBα mediates the exit from naïve pluripotency

    Luis G Palma, Daniel Álvarez-Villanueva ... Anna Bigas
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen

    Aryeh Solomon, Noa Bossel Ben-Moshe ... Roi Avraham
    In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
    1. Neuroscience

    Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

    Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw
    Dentate nucleus neurons can dynamically modulate their activity during a visual attention task, comprising not only sensorimotor but also cognitive attentional components.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations

    Bin Zheng, Meimei Duan ... Peng Zheng
    The identification of a conserved α-helical domain in monkeypox virus H3 protein as critical for heparan sulfate binding unveils a novel therapeutic target, validated through AI and molecular dynamics simulations, offering potential for broad-spectrum antiviral development.
    1. Medicine

    Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state

    Yao Li, Hui Xin ... Wei Zhang
    Low estrogen levels in postmenopausal hypertension are linked to metabolic reprogramming and aortic tissue changes, with L-alpha-aminobutyric acid emerging as a potential protective biomarker.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

    Axelle Amen, Randy Yoo ... Matthijs M Jore
    A naturally acquired human monoclonal antibody recognizes proteins expressed at different stages of the Plasmodium falciparum life cycle through affinity-matured homotypic interactions with glutamate-rich repeats.
    1. Genetics and Genomics

    Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

    Sophie Debaenst, Tamara Jarayseh ... Andy Willaert
    Crispant analysis in zebrafish serves as a powerful tool for the rapid functional screening of genes implicated in bone fragility disorders, like osteogenesis imperfecta and osteoporosis.
    1. Neuroscience

    Outer hair cells stir cochlear fluids

    Choongheon Lee, Mohammad Shokrian ... Jong-Hoon Nam
    Inner-ear drug delivery experiments show that the fluids in the cochlea circulate due to the peristaltic action of motile auditory receptor cells.
    1. Immunology and Inflammation

    B cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size

    Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

    Viktor János Oláh, Jing Wu ... Matthew JM Rowan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid