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    1. Computational and Systems Biology
    2. Physics of Living Systems

    Intraspecific predator interference promotes biodiversity in ecosystems

    Ju Kang, Shijie Zhang ... Xin Wang
    Intraspecific predator interference enables a wide range of consumer species to coexist with a limited variety of resources, explaining the paradox of the plankton and species diversity patterns across ecosystems.
    1. Neuroscience

    PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

    Typhaine Comyn, Thomas Preat ... Pierre-Yves Plaçais
    In neurons of the Drosophila brain’s memory center, PKCδ relays a post-learning dopamine signal to mitochondria, boosting their metabolic activity and thereby unlocking long-term memory formation.
    1. Immunology and Inflammation
    2. Neuroscience

    Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma

    Sachin P Gadani, Saumitra Singh ... Pavan Bhargava
    Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
    Version of Record
    Short Report
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    • Solid
    1. Structural Biology and Molecular Biophysics

    Predicting the sequence-dependent backbone dynamics of intrinsically disordered proteins

    Sanbo Qin, Huan-Xiang Zhou
    SeqDYN, a sequence-based method, accurately predicts the residue-specific transverse relaxation rates of intrinsically disordered proteins.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    PRR adjuvants restrain high stability peptides presentation on APCs

    Bin Li, Jin Zhang ... Chao Wu
    Adjuvants, MPLA and CpG especially, modulate the peptide repertoires presented on the surface of APCs, preferring the presentation of low-affinity exogenous peptides rather than high-affinity peptides.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki

    Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
    A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    Not revised
    Reviewed Preprint v1
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    • Solid
    • Incomplete
    1. Neuroscience

    Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation

    HeeYoung Seon, Dongil Chung
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Evolutionary Biology
    2. Neuroscience

    Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates

    Sebastien Bouret, Emmanuel Paradis ... Cecile Garcia
    Across primates, volumes of specific brain regions relate to specific socio-ecological factors, bridging the gap between neuro-cognitive operations from laboratory studies and challenges primates face in their natural environment.
    1. Neuroscience

    Sub-cone visual resolution by active, adaptive sampling in the human foveola

    Jenny L Witten, Veronika Lukyanova, Wolf M Harmening
    High-resolution foveal imaging and micro-psychophysics reveal that the human oculomotor system finely adjusts drift motion of the eye in an acuity task to enhance retinal sampling, achieving sub-cell resolution.